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YTHDF1 promotes mRNA degradation via YTHDF1-AGO2 interaction and phase separation
Cell Proliferation ( IF 5.9 ) Pub Date : 2021-11-25 , DOI: 10.1111/cpr.13157
Jiong Li 1, 2 , Ke Chen 3 , Xin Dong 1 , Yating Xu 1 , Qi Sun 1 , Honghong Wang 1 , Zhen Chen 1 , Cong Liu 1 , Rong Liu 1 , Zhe Yang 4 , Xiangfei Mei 1 , Rongyu Zhang 5 , Liuping Chang 5 , Zongwen Tian 1 , Jianjun Chen 6 , Kaiwei Liang 1 , Chunjiang He 5 , Mengcheng Luo 1, 2
Affiliation  

YTHDF1 is known as a m6A reader protein, and many researches of YTHDF1 focused on the regulation of mRNA translation efficiency. However, YTHDF1 is also related to RNA degradation, but how YTHDF1 regulates mRNA degradation is indefinite. Liquid-liquid phase separation (LLPS) underlies the formation of membraneless compartments in mammal cells, and there are few reports focused on the correlation of RNA degradation with LLPS. In this research, we focused on the mechanism of YTHDF1 degraded mRNA through LLPS.

中文翻译:

YTHDF1 通过 YTHDF1-AGO2 相互作用和相分离促进 mRNA 降解

YTHDF1被称为am 6 A阅读蛋白,很多关于YTHDF1的研究都集中在mRNA翻译效率的调控上。然而,YTHDF1 也与 RNA 降解有关,但 YTHDF1 如何调节 mRNA 降解是不确定的。液-液相分离 (LLPS) 是哺乳动物细胞中无膜隔室形成的基础,很少有报道关注 RNA 降解与 LLPS 的相关性。在本研究中,我们重点研究了 YTHDF1 通过 LLPS 降解 mRNA 的机制。
更新日期:2022-01-21
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