Ultra-small gold nanoclusters assembled on plasma polymer-modified zeolites: a multifunctional nanohybrid with anti-haemorrhagic and anti-inflammatory properties,Nanoscale

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Ultra-small gold nanoclusters assembled on plasma polymer-modified zeolites: a multifunctional nanohybrid with anti-haemorrhagic and anti-inflammatory properties
Nanoscale ( IF 5.8 ) Pub Date : 2021-11-18 , DOI: 10.1039/d1nr06591b
Laura E González García _{1,

2} , Neethu Ninan _{1,

2} , Johanna Simon _{3,

4} , Rahul Madathiparambil Visalakshan ₁ , Richard Bright _{1,

2} , Satriyo K Wahono ₅ , Kostya Ostrikov ₆ , Volker Mailänder _{3,

4} , Katharina Landfester _{3,

4} , Nirmal Goswami _{1,

7,

8} , Krasimir Vasilev _{1,

2}

Affiliation

Hemostatic agents are pivotal for managing clinical and traumatic bleeding during emergency and domestic circumstances. Herein, a novel functional hybrid nanocomposite material consisting of plasma polymer-modified zeolite 13X and ultra-small gold nanoclusters (AuNCs) was fabricated as an efficient hemostatic agent. The surface of zeolite 13X was functionalised with amine groups which served as binding sites for carboxylate terminated AuNCs. Protein corona studies revealed the enhanced adsorption of two proteins, namely, coagulation factors and plasminogen as a result of AuNCs immobilization on the zeolite surface. The immune response studies showed that the hybrid nanocomposites are effective in reducing inflammation, which combined with a greater attachment of vitronectin, may promote wound healing. The hemostatic potential of the nanocomposite could be directly correlated with their immunomodulatory and anti-haemorrhagic properties. Together, the hybrid nanoengineered material developed in this work could provide a new avenue to tackle life-threatening injuries in civilian and other emergencies.

中文翻译：

组装在等离子体聚合物改性沸石上的超小金纳米团簇：一种具有抗出血和抗炎特性的多功能纳米杂化物

止血剂对于在紧急情况和家庭情况下处理临床和外伤性出血至关重要。在此，制备了一种由等离子体聚合物改性沸石 13X 和超小金纳米团簇 (AuNCs) 组成的新型功能性杂化纳米复合材料，作为一种有效的止血剂。沸石 13X 的表面用胺基团进行了功能化，胺基团作为羧酸盐封端的 AuNCs 的结合位点。蛋白质电晕研究表明，由于 AuNCs 固定在沸石表面，两种蛋白质（即凝血因子和纤溶酶原）的吸附增强。免疫反应研究表明，混合纳米复合材料可有效减少炎症，结合玻连蛋白的更多附着，可促进伤口愈合。纳米复合材料的止血潜力与其免疫调节和抗出血特性直接相关。总之，这项工作中开发的混合纳米工程材料可以为解决平民和其他紧急情况中危及生命的伤害提供新的途径。

更新日期：2021-11-25

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