Conidia from Metarhizium are part of the commercial formulations used worldwide for insect pest control. Among the alternatives proposed to improve conidia production, the use of packed column bioreactors allows controlled processes with higher levels of production and productivity than those obtained with the traditional process in plastic bags. However, problems associated with overheating, low CO₂ removal, and inadequate oxygen supply in packed columns limit the scale-up and operation at an industrial scale.

中文翻译：

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添加球形填料提高了填充柱生物反应器中绿僵菌的分生孢子产量

Metarhizium的分生孢子是全球用于害虫防治的商业配方的一部分。在为提高分生孢子产量而提出的替代方案中，使用填充柱生物反应器可以实现比塑料袋中的传统工艺更高水平的产量和生产率的受控工艺。然而，与过热、低 CO ₂去除率和填充柱中氧气供应不足相关的问题限制了工业规模的放大和操作。