Transcription of eukaryotic protein-coding genes involves co-activator complexes, including TFIID and SAGA. A new study has determined the first high-resolution cryo-EM structure of the human SAGA complex, and has implications for defining SAGA function during multiple stages of eukaryotic transcription.

中文翻译：

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人类 SAGA 共激活复合物的编年史

真核蛋白质编码基因的转录涉及共激活复合物，包括 TFIID 和 SAGA。一项新的研究确定了人类 SAGA 复合体的第一个高分辨率冷冻电镜结构，并对在真核转录的多个阶段定义 SAGA 功能具有重要意义。