A green approach to produce a cellulose-derived biocatalyst containing hydroxamic acids targeted for the neutralization of toxic organophosphates is shown. The cellulose source, rice husk, is among the largest agricultural waste worldwide and can be strategically functionalized, broadening its sustainable application. Herein, rice husk was oxidized in different degrees, leading to carboxylic acid-based colloidal and solid samples. These were functionalized with hydroxamic acids via amide bonds and fully characterized. The hydroxamic acid derived biocatalysts were evaluated in the cleavage of toxic organophosphates, including the pesticide Paraoxon. Catalytic increments reached up to 10⁷-fold compared to non-catalyzed reactions. Most impressively, the materials showed P atom-selectivity and recyclability features. This guarantees only one reaction pathway that leads to less toxic products, hereby, detoxifies. Overall, highly sustainable catalysts are presented, that benefits from waste source, its green functionalization and is successfully employed for the promotion of chemical security of threatening organophosphates. To the best of our knowledge, this is the first report of a hydroxamate-derived rice husk (selectively modified at the C6 of cellulose) and its application in organophosphates reaction.

展示了一种生产含有异羟肟酸的纤维素衍生生物催化剂的绿色方法，该生物催化剂用于中和有毒的有机磷酸盐。纤维素来源稻壳是全球最大的农业废弃物之一，可以战略性地进行功能化，扩大其可持续应用。在这里，稻壳被不同程度地氧化，导致羧酸基胶体和固体样品。这些通过酰胺键用异羟肟酸官能化并完全表征。在分解有毒有机磷酸盐（包括农药对氧磷）中对异羟肟酸衍生的生物催化剂进行了评估。催化增量达到 10 ⁷- 与非催化反应相比 - 倍。最令人印象深刻的是，这些材料显示出 P 原子选择性和可回收性特征。这保证了只有一种反应途径导致毒性较小的产物，从而解毒。总体而言，提出了高度可持续的催化剂，该催化剂受益于废物来源，其绿色功能化，并成功用于促进具有威胁性的有机磷酸盐的化学安全性。据我们所知，这是首次报道异羟肟酸盐衍生的稻壳（在纤维素的 C6 处选择性修饰）及其在有机磷酸盐反应中的应用。