Extracerebral microvascular dysfunction is related to brain MRI markers of cerebral small vessel disease: The Maastricht Study,GeroScience

当前位置： X-MOL 学术 › Geroscience › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Extracerebral microvascular dysfunction is related to brain MRI markers of cerebral small vessel disease: The Maastricht Study
GeroScience ( IF 5.3 ) Pub Date : 2021-11-23 , DOI: 10.1007/s11357-021-00493-0
Maud van Dinther _{1,

2} , Miranda T Schram _{3,

4} , Jacobus F A Jansen _{4,

5} , Walter H Backes _{2,

4,

5} , Alfons J H M Houben _{2,

3} , Tos T J M Berendschot _{4,

6,

7} , Casper G Schalkwijk _{2,

3} , Coen D A Stehouwer _{2,

3} , Robert J van Oostenbrugge _{1,

2,

4} , Julie Staals _{1,

2}

Affiliation

Background

Cerebral small vessel disease (cSVD) is a late consequence of cerebral microvascular dysfunction (MVD). MVD is hard to measure in the brain due to its limited accessibility. Extracerebral MVD (eMVD) measures can give insights in the etiology of cerebral MVD, as MVD may be a systemic process. We aim to investigate whether a compound score consisting of several eMVD measures is associated with structural cSVD MRI markers.

Methods

Cross-sectional data of the population-based Maastricht Study was used (n = 1872, mean age 59 ± 8 years, 49% women). Measures of eMVD included flicker light-induced retinal arteriolar and venular dilation response (retina), albuminuria and glomerular filtration rate (kidney), heat-induced skin hyperemia (skin), and plasma biomarkers of endothelial dysfunction (sICAM-1, sVCAM-1, sE-selectin, and von Willebrand factor). These measures were standardized into z scores and summarized into a compound score. Linear and logistic regression analyses were used to investigate the associations between the compound score and white matter hyperintensity (WMH) volume, and the presence of lacunes and microbleeds, as measured by brain MRI.

Results

The eMVD compound score was associated with WMH volume independent of age, sex, and cardiovascular risk factors (St β 0.057 [95% CI 0.010–0.081], p value 0.01), but not with the presence of lacunes (OR 1.011 [95% CI 0.803–1.273], p value 0.92) or microbleeds (OR 1.055 [95% CI 0.896–1.242], p value 0.52).

Conclusion

A compound score of eMVD is associated with WMH volume. Further research is needed to expand the knowledge about the role of systemic MVD in the pathophysiology of cSVD.

中文翻译：

脑外微血管功能障碍与脑小血管疾病的脑 MRI 标志物有关：马斯特里赫特研究

背景

脑小血管疾病 (cSVD) 是脑微血管功能障碍 (MVD) 的晚期后果。由于可访问性有限，MVD 很难在大脑中测量。脑外 MVD (eMVD) 测量可以深入了解脑 MVD 的病因，因为 MVD 可能是一个系统性过程。我们的目标是调查由几个 eMVD 测量组成的复合评分是否与结构 cSVD MRI 标记相关。

方法

使用了基于人群的马斯特里赫特研究的横断面数据（n = 1872，平均年龄 59 ± 8 岁，49% 的女性）。eMVD 的测量包括闪烁光诱导的视网膜小动脉和小静脉扩张反应（视网膜）、蛋白尿和肾小球滤过率（肾）、热诱导的皮肤充血（皮肤）和内皮功能障碍的血浆生物标志物（sICAM-1、sVCAM-1 、sE-选择素和 von Willebrand 因子）。这些测量被标准化为z分数并总结为复合分数。线性和逻辑回归分析用于研究复合评分与白质高信号 (WMH) 体积之间的关联，以及通过脑 MRI 测量的腔隙和微出血的存在。

结果

eMVD 复合评分与 WMH 体积相关，与年龄、性别和心血管危险因素无关（St β 0.057 [95% CI 0.010–0.081]，p值 0.01），但与腔隙的存在无关（OR 1.011 [95% CI 0.803–1.273]，p值 0.92）或微出血（OR 1.055 [95% CI 0.896–1.242]，p值 0.52）。