Prenatal Exposure to Disinfection Byproducts and Intrauterine Growth in a Chinese Cohort,Environmental Science & Technology

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Prenatal Exposure to Disinfection Byproducts and Intrauterine Growth in a Chinese Cohort
Environmental Science & Technology ( IF 10.8 ) Pub Date : 2021-11-23 , DOI: 10.1021/acs.est.1c04926
Chong Liu _{1,

2} , Yang Sun _{3,

4} , Vicente Mustieles _{5,

6} , Ying-Jun Chen ₇ , Li-Li Huang ₈ , Yan-Ling Deng _{1,

2} , Yi-Xin Wang ₉ , Wen-Qing Lu _{1,

2} , Carmen Messerlian _{3,

4}

Affiliation

Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China.
Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China.
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, United States.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, United States.
Center for Biomedical Research (CIBM), University of Granada, Granada 18016, Spain.
Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Madrid 28029, Spain.
Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, China.
School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, United States.

Disinfection byproduct (DBP) exposure has been associated with birth size, pregnancy oxidative stress, and other adverse perinatal outcomes. However, little is known about the potential effect of prenatal DBP exposure on intrauterine growth. The present study included 1516 pregnant women from the Xiaogan Disinfection By-Products (XGDBP) birth cohort who were measured for four blood trihalomethanes [i.e., chloroform (TCM), bromodichloromethane (BDCM), dibromochloromethane (DBCM), and bromoform (TBM)] and two urinary haloacetic acids [i.e., dichloroacetic acid (DCAA) and trichloroacetic acid (TCAA)] across pregnancy trimesters. Second- and third-trimester fetal ultrasound measures of the abdominal circumference (AC), head circumference, biparietal diameter, femur length, and estimated fetal weight and birth weight were converted into z-scores. After adjusting for potential confounders, linear mixed models showed a decreasing AC z-score across tertiles of blood brominated THM (Br-THMs, the sum of BDCM, DBCM, and TBM) and total THM (THM4, the sum of Br-THMs and TCM) concentrations (both p for trend <0.01). We also observed a decreasing AC z-score across categories of blood TBM during pregnancy trimesters (p for trend = 0.03). Urinary haloacetic acids were unrelated to fetal growth parameters. In summary, prenatal exposure to THMs, particularly during the first trimester, was associated with reduced fetal abdominal circumference.

更新日期：2021-12-07

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