Investigators report greater parietal tau deposition and alternate frontoparietal network involvement in early onset Alzheimer’s Disease (EOAD) with onset <65 years as compared with typical late onset AD (LOAD). To determine whether clinical brain MRI volumes reflect these differences in EOAD compared with LOAD. This study investigated the clinical MRI scans of 45 persons with Clinically Probable AD with onset <65 years, and compared them to 32 with Clinically Probable AD with onset ≥65 years. Brain volumes on their T1 MRI scans were quantified with a volumetric program. Receiver operating curve analyses were performed. Persons with EOAD had significantly smaller parietal lobes (volumetric percentiles) than LOAD. Late onset Alzheimer’s Disease had a smaller left putamen and hippocampus. Area Under the Curve was 96.5% with brain region delineation of EOAD compared to LOAD. This study indicates parietal atrophy less than 30% of normal on clinical MRI scans is suggestive of EOAD compared to LOAD.

研究人员报告说，与典型的迟发性 AD (LOAD) 相比，在发病 <65 岁的早发性阿尔茨海默病 (EOAD) 中，顶叶 tau 沉积和交替的额顶叶网络受累更多。确定临床脑 MRI 体积是否反映了 EOAD 与 LOAD 相比的这些差异。本研究调查了 45 名发病年龄小于 65 岁的临床可能 AD 患者的临床 MRI 扫描，并将他们与 32 名发病年龄≥65 岁的临床可能 AD 患者进行了比较。他们的 T1 MRI 扫描中的脑容量是用容量程序量化的。进行了接受者操作曲线分析。EOAD 患者的顶叶（体积百分位数）明显小于 LOAD。迟发性阿尔茨海默病的左壳核和海马体较小。曲线下面积为 96 。与 LOAD 相比，EOAD 的大脑区域描绘为 5%。该研究表明，与 LOAD 相比，临床 MRI 扫描中顶叶萎缩低于正常值的 30% 提示 EOAD。