Purpose: 

The aim of this study was to quantitatively evaluate dry eye test parameters of pediatric patients with and without vitamin D deficiency (VDD) in type 1 diabetes mellitus.

Methods: 

In this prospective cross-sectional study, the Ocular Surface Disease Index, Schirmer test, tear film breakup time, corneal staining score, and anterior segment optical coherence tomography were used to determine the dry eye test parameters of pediatric patients with type 1 diabetes mellitus (T1-DMPs) (group 1) and a healthy pediatric control group (group 2). Group 1 was divided into 2 subgroups based on their vitamin D status: group 1a, who had a VDD, and group 1b, who had vitamin D levels that were within the normal range.

Results: 

This study compared 90 eyes of 90 pediatric T1-DMPs with 80 eyes of 80 healthy controls. The demographic characteristics of the groups were similar (P > 0.05). The tear film breakup time, Schirmer test, corneal staining score, and values of the tear meniscus height and area were observed to have been lower in the patients in group 1a than the healthy pediatric control group, at P < 0.001. The same parameters were statistically significantly lower in the patients in group 1a when compared with group 1b (P < 0.05 for both).

Conclusions: 

The tear measurements of the pediatric T1-DMPs were lower than those in the healthy pediatric control group. The accompanying VDD made this situation more pronounced.

中文翻译：

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患有或不患有维生素 D 缺乏的 1 型糖尿病儿童泪液半月板的变化分析

目的： 

本研究的目的是定量评估1 型糖尿病中患有和不患有维生素 D 缺乏(VDD) 的儿科患者的干眼测试参数。

方法： 

在这项前瞻性横断面研究中，使用眼表疾病指数、Schirmer试验、泪膜破裂时间、角膜染色评分和眼前节光学相干断层扫描来确定1型糖尿病儿科患者的干眼测试参数。 T1-DMP）（第 1 组）和健康儿科对照组（第 2 组）。第 1 组根据维生素 D 状况分为 2 个亚组：第 1a 组具有 VDD，第 1b 组维生素 D 水平在正常范围内。

结果： 

这项研究将 90 名儿童 T1-DMP 的 90 只眼睛与 80 名健康对照的 80 只眼睛进行了比较。各组的人口统计学特征相似（P > 0.05）。1a 组患者的泪膜破裂时间、Schirmer 试验、角膜染色评分以及泪液半月板高度和面积值均低于健康儿科对照组，P < 0.001。与1b组相比，1a组患者的相同参数具有统计学意义显着降低（均P < 0.05）。

结论： 

儿科 T1-DMP 的泪液测量值低于健康儿科对照组。伴随的 VDD 使这种情况更加明显。