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Aberrant crosstalk between insulin signaling and mTOR in young Down syndrome individuals revealed by neuronal-derived extracellular vesicles
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2021-11-23 , DOI: 10.1002/alz.12499
Marzia Perluigi 1 , Anna Picca 2 , Elita Montanari 3 , Riccardo Calvani 2 , Federico Marini 4 , Roberto Matassa 5 , Antonella Tramutola 1 , Alberto Villani 6 , Giuseppe Familiari 5 , Fabio Di Domenico 1 , D Allan Butterfield 7 , Kenneth J Oh 8 , Emanuele Marzetti 2, 9 , Diletta Valentini 6 , Eugenio Barone 1
Affiliation  

Intellectual disability, accelerated aging, and early-onset Alzheimer-like neurodegeneration are key brain pathological features of Down syndrome (DS). Although growing research aims at the identification of molecular pathways underlying the aging trajectory of DS population, data on infants and adolescents with DS are missing.

中文翻译:

神经元来源的细胞外囊泡揭示了年轻唐氏综合症患者胰岛素信号和 mTOR 之间的异常串扰

智力障碍、加速衰老和早发性阿尔茨海默样神经变性是唐氏综合症 (DS) 的关键脑病理特征。尽管越来越多的研究旨在确定 DS 人群衰老轨迹背后的分子途径,但缺少 DS 婴儿和青少年的数据。
更新日期:2021-11-23
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