tamine could improve depressive symptoms rapidly and safely during the hospital stay. METHODS: This was a randomized, placebo-controlled, and double-blinded trial. Patients with moderate-to-severe depressive symptoms undergoing elective supratentorial brain tumor resection were randomized to intravenously receive either (1) 0.5 mg·kg−1 ketamine for 40 minutes or (2) an identical volume of normal saline. The primary outcome was treatment response on postoperative day 3, defined as a ≥50% reduction from the baseline depressive score. The secondary outcomes included the rate of remission and safety outcomes. The Montgomery-Åsberg Depression Rating Scale was applied by trained psychiatrists to evaluate depressive symptoms. RESULTS: A total of 84 neurosurgical patients were enrolled in the trial. The response rate was increased by the administration of ketamine (41.5% [17/41] vs 16.3% [7/43]; relative risk [RR]: 2.51, 95% confidence interval [CI], 1.18–5.50) relative to the administration of placebo at 3 days. Furthermore, the remission rate at discharge (29.3% [12/41] vs 7.0% [3/43]; RR: 4.20, 95% CI, 1.28–13.80) was also improved by ketamine. No psychotic symptoms or adverse events were reported to be substantially higher in the ketamine group. CONCLUSIONS: The trial indicates that the intraoperative administration of ketamine could alleviate moderate-to-severe depressive symptoms in neurosurgical patients without worsening safety....

中文翻译：

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氯胺酮减轻接受颅内肿瘤切除术的患者的抑郁症状：一项随机对照试验

tamine 可以在住院期间快速、安全地改善抑郁症状。方法：这是一项随机、安慰剂对照和双盲试验。接受选择性幕上脑肿瘤切除术的中度至重度抑郁症状患者随机接受静脉注射 (1) 0.5 mg·kg-1 氯胺酮 40 分钟或 (2) 相同体积的生理盐水。主要结果是术后第 3 天的治疗反应，定义为从基线抑郁评分降低 50% 以上。次要结果包括缓解率和安全性结果。Montgomery-Åsberg 抑郁量表由训练有素的精神科医生应用来评估抑郁症状。结果：共有 84 名神经外科患者参加了试验。相对于氯胺酮给药，缓解率增加（41.5% [17/41] vs 16.3% [7/43]；相对风险 [RR]：2.51，95% 置信区间 [CI]，1.18-5.50）第 3 天服用安慰剂。此外，氯胺酮还提高了出院时的缓解率（29.3% [12/41] vs 7.0% [3/43]；RR：4.20，95% CI，1.28-13.80）。据报道，氯胺酮组没有明显更高的精神病症状或不良事件。结论：该试验表明，术中使用氯胺酮可以缓解神经外科患者的中度至重度抑郁症状，而不会降低安全性。... 氯胺酮还提高了出院时的缓解率（29.3% [12/41] vs 7.0% [3/43]；RR：4.20，95% CI，1.28-13.80）。据报道，氯胺酮组没有明显更高的精神病症状或不良事件。结论：该试验表明，术中使用氯胺酮可以缓解神经外科患者的中度至重度抑郁症状，而不会降低安全性。... 氯胺酮还提高了出院时的缓解率（29.3% [12/41] vs 7.0% [3/43]；RR：4.20，95% CI，1.28-13.80）。据报道，氯胺酮组没有明显更高的精神病症状或不良事件。结论：该试验表明，术中使用氯胺酮可以缓解神经外科患者的中度至重度抑郁症状，而不会降低安全性。...