Bacteria-infected wounds have imposed serious challenges in human health whereas the abuse of antibiotics makes bacteria drug-resistant and becoming more and more difficult to deal with. Herein, we developed a drug-free three-layered photothermal bactericide from inside to outside consisting of copper sulfide (CuS), gold (Au) and zinc-doped Prussian blue analogues (ZnPBA) (named as CuS@Au@ZnPBA). The CuS@Au@ZnPBA was demonstrated to possess remarkably-improved photothermal property and excellent biosafety. Local heat generated by CuS@Au@ZnPBA under the irradiation of 808 nm laser enables efficient bacteria ablation in vitro and in a mouse model of cutaneous wound infection. Meanwhile, the released zinc ions (Zn²⁺) could upregulate the genes involved in collagen deposition to accelerate wound healing. Overall, the finely-designed nanocomposites can serve as a promising kind of antibacterial alternative to current antibiotic therapies against bacterial wound infections.

细菌感染的伤口给人类健康带来了严峻的挑战，而抗生素的滥用使细菌产生耐药性并且变得越来越难以处理。在此，我们开发了一种由内到外的无药物三层光热杀菌剂，由硫化铜（CuS）、金（Au）和锌掺杂的普鲁士蓝类似物（ZnPBA）组成（命名为CuS@Au@ZnPBA）。CuS@Au@ZnPBA 被证明具有显着改善的光热性能和优异的生物安全性。CuS@Au@ZnPBA 在 808 nm 激光照射下产生的局部热量能够在体外和皮肤伤口感染的小鼠模型中进行有效的细菌消融。同时，释放的锌离子（Zn ²⁺) 可以上调参与胶原蛋白沉积的基因以加速伤口愈合。总体而言，精心设计的纳米复合材料可以作为目前针对细菌性伤口感染的抗生素疗法的一种有前途的抗菌替代品。