Although chimeric antigen receptor T cells demonstrated remarkable efficacy in patients with chemo-resistant hematologic malignancies, a significant portion still resist or relapse. This immune evasion may be due to CAR T cells dysfunction, a hostile tumor microenvironment, or resistant cancer cells. Here, we review the intrinsic resistance mechanisms of cancer cells to CAR T cell therapy and potential strategies to circumvent them.

中文翻译：

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为生存而生：癌细胞如何抵抗 CAR T 细胞疗法


尽管嵌合抗原受体 T 细胞在化疗耐药的血液恶性肿瘤患者中表现出显着的疗效，但仍有很大一部分患者出现耐药或复发。这种免疫逃避可能是由于 CAR T 细胞功能障碍、不利的肿瘤微环境或耐药癌细胞造成的。在这里，我们回顾了癌细胞对 CAR T 细胞疗法的内在耐药机制以及规避这些机制的潜在策略。