Chronic heart failure with reduced ejection fraction remains a major health issue. To date, no reliable biomarker is available to predict reduced left ventricular ejection fraction (LV-EF). We aimed to identify novel circulating biomarkers for reduced left ventricular function using untargeted serum metabolomics in two independent patient cohorts.

中文翻译：

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非靶向代谢组学将多胺代谢物 acisoga 确定为左心室功能降低的新型生物标志物


射血分数降低的慢性心力衰竭仍然是一个主要的健康问题。迄今为止，尚无可靠的生物标志物可用于预测左心室射血分数（LV-EF）降低。我们的目的是在两个独立的患者队列中使用非靶向血清代谢组学来识别左心室功能降低的新型循环生物标志物。