Microglia form barriers that attenuate the propagation of amyloid pathology in Alzheimer’s disease. d’Errico et al. have uncovered a paradoxical ability of microglia to spread amyloid plaques, which depends on the transcription factor IRF8. Here, we highlight the contexts in which this may happen and discuss outstanding questions.

中文翻译：

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阿尔茨海默病中小胶质细胞的双面行为

小胶质细胞形成屏障，减弱阿尔茨海默病中淀粉样蛋白病理的传播。d'Errico 等人。发现了小胶质细胞传播淀粉样蛋白斑块的自相矛盾的能力，这取决于转录因子 IRF8。在这里，我们强调可能发生这种情况的背景并讨论悬而未决的问题。