Background Cardiovascular diseases are the second most common cause of mortality among cancer survivors, after death from cancer. We sought to assess the impact of cancer on the short-term outcomes of acute myocardial infarction (AMI), by analysing data obtained from a large-scale database. Methods This study was based on the Diagnosis Procedure Combination database in the Japanese Registry of All Cardiac and Vascular Diseases and the Diagnosis Procedure Combination. We identified patients who were hospitalised for primary AMI between April 2012 and March 2017. Propensity Score (PS) was estimated with logistic regression model, with cancer as the dependent variable and 21 clinically relevant covariates. The main outcome was in-hospital mortality. Results We split 1 52 208 patients into two groups with or without cancer. Patients with cancer tended to be older (cancer group 73±11 years vs non-cancer group 68±13 years) and had smaller body mass index (cancer group 22.8±3.6 vs non-cancer 23.9±4.3). More patients in the non-cancer group had hypertension or dyslipidaemia than their cancer group counterparts. The non-cancer group also had a higher rate of percutaneous coronary intervention (cancer 92.6% vs non-cancer 95.2%). Patients with cancer had a higher 30-day mortality (cancer 6.0% vs non-cancer 5.3%) and total mortality (cancer 8.1% vs non-cancer 6.1%) rate, but this was statistically insignificant after PS matching. Conclusion Cancer did not significantly impact short-term in-hospital mortality rates after hospitalisation for primary AMI. Data are available upon reasonable request. Individual anonymsed data supporting the analyses contained in the manuscript will be made available upon reasonable written request from researchers whose proposed use of the data for a specific purpose has been approved.

中文翻译：

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癌症对原发性急性心肌梗死后短期住院死亡率的影响

背景 心血管疾病是癌症幸存者死亡的第二大常见原因，仅次于癌症死亡。我们试图通过分析从大型数据库中获得的数据来评估癌症对急性心肌梗死 (AMI) 短期结果的影响。方法 本研究基于日本所有心脏和血管疾病登记处的诊断程序组合数据库和诊断程序组合。我们确定了 2012 年 4 月至 2017 年 3 月期间因原发性 AMI 住院的患者。倾向评分 (PS) 采用逻辑回归模型估计，癌症作为因变量和 21 个临床相关协变量。主要结果是住院死亡率。结果 我们将 1 52 208 名患者分为患有或未患癌症的两组。癌症患者往往年龄较大（癌症组 73±11 岁对非癌症组 68±13 岁）并且体重指数较小（癌症组 22.8±3.6 对非癌症组 23.9±4.3）。与癌症组对应的患者相比，非癌症组中更多的患者患有高血压或血脂异常。非癌症组的经皮冠状动脉介入治疗率也较高（癌症组为 92.6%，非癌症组为 95.2%）。癌症患者的 30 天死亡率（癌症 6.0% 对非癌症 5.3%）和总死亡率（癌症 8.1% 对非癌症 6.1%）率较高，但在 PS 匹配后这在统计学上不显着。结论 癌症对原发性 AMI 住院后的短期住院死亡率没有显着影响。可根据合理要求提供数据。