Background The Toronto Aortic Stenosis Quality of Life Questionnaire (TASQ) is a validated instrument for assessing quality of life (QoL) in patients with severe aortic stenosis (AS). In this study, we evaluated health status outcomes, based on the TASQ, in patients with severe AS undergoing transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR). Methods The TASQ registry was a prospective observational registry. Patients with severe AS from nine centres in Europe and one in Canada underwent either SAVR or transfemoral TAVR. Patients completed the TASQ, Kansas City Cardiomyopathy Questionnaire and Short Form-12 V.2 prior to the intervention, predischarge, and at 30-day and 3-month follow-ups. Primary end point was the TASQ score. Results In both the TAVR (n=137) and SAVR (n=137) cohorts, significant increases were observed in all three scores. The overall TASQ score improved as did all but one of the individual domains at 3 months after the intervention (p<0.001). TASQ health expectations were the only domain which worsened (p<0.001). Across TASQ subscores, significant changes were evident from the time of discharge in the TAVR and 30-day follow-up in the SAVR cohort. In a categorical analysis of the TASQ, 39.7% of the TAVR group and 35.0% of the SAVR group had a substantially improved health status at 3 months compared with baseline. Conclusions The TASQ captured changes in QoL among patients with severe AS who were treated with TAVR or SAVR. QoL improved substantially after either intervention, as indicated by changes in the TASQ overall score at 3 months. Trial registration number [NCT03186339][1]. Data are available upon reasonable request. [1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT03186339&atom=%2Fopenhrt%2F8%2F2%2Fe001821.atom

中文翻译：

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使用多伦多主动脉瓣狭窄生活质量问卷经导管或外科主动脉瓣置换术后的生活质量

背景多伦多主动脉瓣狭窄生活质量问卷 (TASQ) 是一种经过验证的工具，用于评估严重主动脉瓣狭窄 (AS) 患者的生活质量 (QoL)。在这项研究中，我们基于 TASQ 评估了接受经导管主动脉瓣置换术 (TAVR) 或外科主动脉瓣置换术 (SAVR) 的严重 AS 患者的健康状况结果。方法 TASQ 登记是一项前瞻性观察登记。来自欧洲 9 个中心和加拿大 1 个中心的严重 AS 患者接受了 SAVR 或经股动脉 TAVR。患者在干预前、出院前以及 30 天和 3 个月的随访中完成了 TASQ、堪萨斯城心肌病问卷和 Short Form-12 V.2。主要终点是 TASQ 评分。结果 在 TAVR (n=137) 和 SAVR (n=137) 队列中，在所有三个分数中都观察到显着增加。在干预后 3 个月，总体 TASQ 评分与除一个单独领域外的所有领域均有所改善（p<0.001）。TASQ 健康预期是唯一恶化的领域（p<0.001）。在 TASQ 子评分中，从 TAVR 的出院时间和 SAVR 队列的 30 天随访时间来看，显着变化是明显的。在对 TASQ 的分类分析中，与基线相比，39.7% 的 TAVR 组和 35.0% 的 SAVR 组在 3 个月时的健康状况显着改善。结论 TASQ 反映了接受 TAVR 或 SAVR 治疗的严重 AS 患者的生活质量变化。正如 3 个月时 TASQ 总分的变化所表明的那样，在任何一种干预后，生活质量都得到了显着改善。试用注册号 [NCT03186339][1]。可根据合理要求提供数据。[1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT03186339&atom=%2Fopenhrt%2F8%2F2%2Fe001821.atom