ABSTRACT

Purpose

To update the incidence of uveitis in a Midwestern U.S. county population.

Methods

Retrospective population-based cohort study. All Olmsted County, Minnesota residents diagnosed with uveitis from January 1, 2006 to December 31, 2015 were identified via the Rochester Epidemiology Project. Diagnoses were confirmed by a uveitis specialist.

Results

There were 371 incident uveitis cases, yielding an overall age- and sex-adjusted incidence rate of 26.9 per 100,000 per year (95% CI: 24.1–29.7). Females accounted for 202 (54.4%) cases, 306 (82.5%) were White, and 299 (80.6%) were anterior uveitis. Highest incidence was observed in patients ≥65 years old. No difference in incidence existed between sexes (p = .17). Incidence rates increased with age for uveitis overall (all anatomic subtypes) (p < .001), anterior uveitis (p < .001), and posterior uveitis (p < .001). Idiopathic uveitis accounted for 168 (45.3%) cases, more frequently diagnosed in females (50.0%) than males (39.6%) (p = .05).

Conclusion

Uveitis incidence increased 1.6-fold over a 50-year span in this predominately White U.S. Midwestern county population.

中文翻译：

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明尼苏达州奥姆斯特德县葡萄膜炎的流行病学：基于人群的随访研究

 抽象的

 目的

更新美国中西部县人口葡萄膜炎的发病率。

 方法

基于人群的回顾性队列研究。 2006年1月1日至2015年12月31日期间，明尼苏达州奥姆斯特德县所有被诊断患有葡萄膜炎的居民均通过罗切斯特流行病学项目进行了识别。葡萄膜炎专家确认了诊断。

 结果

共有 371 例葡萄膜炎病例，经年龄和性别调整后的总体发病率为每年每 100,000 人 26.9 例（95% CI：24.1-29.7）。女性占202例（54.4%），白人306例（82.5%），前葡萄膜炎299例（80.6%）。 ≥65 岁的患者发病率最高。性别之间的发病率没有差异 ( p = .17)。总体葡萄膜炎（所有解剖亚型）（ p < .001）、前葡萄膜炎（ p < .001）和后葡萄膜炎（ p < .001）的发病率随着年龄的增长而增加。特发性葡萄膜炎占 168 例 (45.3%)，女性 (50.0%) 的诊断频率高于男性 (39.6%) ( p = .05)。

 结论

在美国中西部这个以白人为主的县，葡萄膜炎的发病率在 50 年间增加了 1.6 倍。