ABSTRACT

Purpose

To evaluate the rates of Herpes Simplex Virus types 1 (HSV-1) and 2 (HSV-2) in ocular specimens.

Methods

Retrospective case series of all patients with a positive laboratory evaluation for ocular HSV performed at the Auckland District Health Board, Auckland, New Zealand between 1 January 2006 and 31 December 2017 were included in the study.

Results

A total of 423 specimens were positive for HSV-1 (99.3%, n = 419) or HSV-2 (0.7%; n = 4). The majority of positive tests were identified through DNA amplification (n = 352; 83%) testing while the remainder were obtained by viral culture (n = 71; 17%). Ocular disease caused by HSV-2 in this study included acute retinal necrosis (n = 2), keratitis (n = 1), and blepharitis (n = 1).

Conclusions

HSV type 2 is a rare cause of ocular and peri-ocular infection but may cause severe, vision threatening disease.

中文翻译：

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眼部和眼周标本中 1 型和 2 型单纯疱疹病毒的感染率

摘要

目的

评估眼标本中 1 型单纯疱疹病毒 (HSV-1) 和 2 型 (HSV-2) 的感染率。

方法

该研究包括 2006 年 1 月 1 日至 2017 年 12 月 31 日期间在新西兰奥克兰奥克兰地区卫生委员会进行的所有眼部 HSV 实验室评估呈阳性的患者的回顾性病例系列。

结果

共有 423 个标本呈 HSV-1（99.3%，n = 419）或 HSV-2（0.7%；n = 4）阳性。大多数阳性测试是通过 DNA 扩增（n = 352；83%）测试确定的，而其余测试是通过病毒培养获得的（n = 71；17%）。本研究中由 HSV-2 引起的眼部疾病包括急性视网膜坏死 (n = 2)、角膜炎 (n = 1) 和睑缘炎 (n = 1)。

结论

2 型 HSV 是眼部和眼周感染的罕见病因，但可能导致严重的、威胁视力的疾病。