ABSTRACT

Purpose

To report a case of acute retinal necrosis (ARN) after receiving COVID-19 vaccination.

Methods

A case report

Results

A 78-year-old man complained of blurred vision and floaters in the right eye 2 days after receiving BNT162b2 mRNA-based COVID-19 vaccine and was referred to our hospital with worsening visual acuity after 7 days. He had no systemic symptoms and no history of systemic diseases. Ophthalmic examination revealed white-yellowish placoid lesions spreading to the entire circumference of the retina, and temporal and upper lesions extending to the posterior pole, although anterior inflammation and vitreous opacity were mild. Diagnostic and therapeutic vitrectomy was performed, and VZV-DNA was detected by comprehensive PCR using a vitreous fluid sample. The ocular inflammation subsided by systemic administration of antivirals and corticosteroids. However, total retinal detachment requiring repeat vitrectomy using silicone oil occurred after the second vaccination.

Conclusion

ARN associated with VZV reactivation may develop after SARS-CoV-2 mRNA vaccination.

中文翻译：

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接种 COVID-19 疫苗后水痘带状疱疹病毒再激活导致急性视网膜坏死一例

摘要

目的

报告一例接种 COVID-19 疫苗后发生急性视网膜坏死 (ARN) 的病例。

方法

病例报告

结果

一名 78 岁的男性在接受基于 BNT162b2 mRNA 的 COVID-19 疫苗后 2 天抱怨视力模糊和右眼有飞蚊症，并在 7 天后因视力恶化被转诊到我们医院。无全身症状，无全身性疾病史。眼科检查显示，尽管前部炎症和玻璃体混浊轻微，但白黄色的翼状病变扩散到整个视网膜周围，颞部和上部病变延伸到后极。进行了诊断和治疗性玻璃体切除术，并使用玻璃体液样本通过综合 PCR 检测了 VZV-DNA。眼部炎症通过抗病毒药物和皮质类固醇的全身给药而消退。然而，

结论

SARS-CoV-2 mRNA 疫苗接种后可能会出现与 VZV 再激活相关的 ARN。