ABSTRACT

Purpose

To retrospectively review the clinical characteristics of patients with herpes simplex virus type 2 (HSV-2) blepharokeratoconjunctivitis.

Methods

Laboratory-proven HSV-2 blepharokeratoconjunctivitis cases were reviewed between 1995 and 2021.

Results

Ten of 725 (1.4%) patients had HSV-2 infection. Data were available for nine patients. Associated conditions included neonatal herpes (1/9, 11%), severe atopy (1/9, 11%), genital herpes (2/9, 22%), and systemic immune disorders (2/9, 22%). The most common presenting finding was pain and blurred vision (55.5%). Two patients (22%) had dendritic lesions and one patient (11%) had reduced corneal sensation. Complete resolution was reported in four patients (44.5%). Recurrence was noted in four patients (44.5%) despite antiviral prophylaxis. Corneal complications included scarring and neovascularization. The visual acuity at the last follow-up was 20/40 or worse in four patients (44.5%).

Conclusions

HSV-2 is an uncommon cause of keratitis. Dendrites and loss of corneal sensation were uncommon. Recurrence was noted despite antiviral prophylaxis.

中文翻译：

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单纯疱疹病毒2型睑角结膜炎

摘要

目的

回顾性分析单纯疱疹病毒2型（HSV-2）睑角结膜炎患者的临床特征。

方法

在 1995 年至 2021 年期间审查了经实验室证实的 HSV-2 眼睑角结膜炎病例。

结果

725 名 (1.4%) 患者中有 10 名患有 HSV-2 感染。有 9 名患者的数据可用。相关疾病包括新生儿疱疹 (1/9, 11%)、严重特应性 (1/9, 11%)、生殖器疱疹 (2/9, 22%) 和全身免疫疾病 (2/9, 22%)。最常见的表现是疼痛和视力模糊（55.5%）。两名患者 (22%) 有树突状病变，一名患者 (11%) 有角膜感觉减退。4 名患者（44.5%）报告完全消退。尽管进行了抗病毒预防，仍有 4 名患者 (44.5%) 出现复发。角膜并发症包括疤痕和新血管形成。4 名患者 (44.5%) 在最后一次随访时的视力为 20/40 或更差。

结论

HSV-2 是一种罕见的角膜炎病因。树突和角膜感觉丧失并不常见。尽管进行了抗病毒预防，但仍注意到复发。