Cancer will soon become the leading cause of death in every country in the twenty-first century. This study aimed to analyze the mortality and morbidity of 29 types of cancer in 204 countries or regions from 1990 to 2019 to guide global cancer prevention and control. Detailed information for 29 cancer groups was collected from the Global Burden of Disease Study in 2019. The age-standardized incidence rate (ASIR) and age-standardized death rate (ASDR) of the 29 cancer groups were calculated based on sex, age, region, and country. In addition, separate analyses were performed for major cancer types. In 2019, more than 10 million people died from cancer, which was approximately twice the number in 1990. Tracheal, bronchus, and lung (TBL) cancers collectively showed the highest death rate, and the ASDR of pancreatic cancer increased by 24%, which was cancer with the highest case fatality rate (CFR). The global cancer ASIR showed an increasing trend, with testicular cancer, thyroid cancer, and malignant skin melanoma showing a significant increase. The ASDR and ASIR of cancer in males were about 1.5 times higher than that in females. Individuals over 50 years had the highest risk of developing cancer, with incidences and deaths in this age group accounting for more than 85% of cancers in all age groups. Asia has the heaviest cancer burden due to its high population density, with esophageal cancer in this region accounting for 53% of the total fatalities related to this type of cancer in the world. In addition, the mortality and morbidity of most cancers increased with the increase in the development or socio-demographic index (SDI) in the SDI regions based on the World Bank's Human Development Index (HDI), with cancer characteristics varying in the different countries globally. The global cancer burden continues to increase, with substantial mortality and morbidity differences among the different regions, ages, countries, gender, and cancer types. Effective and locally tailored cancer prevention and control measures are essential in reducing the global cancer burden in the future.

中文翻译：

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2019 年 29 个癌症组的全球、区域和国家癌症发病率和死亡率以及 1990-2019 年全球癌症负担的趋势分析

癌症将很快成为二十一世纪每个国家的主要死因。本研究旨在分析1990-2019年204个国家或地区29种癌症的死亡率和发病率，以指导全球癌症防控。2019年全球疾病负担研究收集了29个癌症组的详细信息。根据性别、年龄、地区计算了29个癌症组的年龄标准化发病率（ASIR）和年龄标准化死亡率（ASDR） ，和国家。此外，对主要癌症类型进行了单独分析。2019 年有超过 1000 万人死于癌症，大约是 1990 年的两倍。气管癌、支气管癌和肺癌 (TBL) 癌症的死亡率共同最高，胰腺癌的 ASDR 增加了 24%，这是病死率（CFR）最高的癌症。全球癌症ASIR呈上升趋势，睾丸癌、甲状腺癌、恶性皮肤黑色素瘤呈明显上升趋势。男性癌症的 ASDR 和 ASIR 比女性高约 1.5 倍。50 岁以上的人患癌症的风险最高，该年龄组的发病率和死亡人数占所有年龄组癌症的 85% 以上。由于人口密度高，亚洲的癌症负担最重，该地区的食道癌占全球与此类癌症相关的总死亡人数的 53%。此外，根据世界银行的数据，大多数癌症的死亡率和发病率随着 SDI 地区的发展或社会人口指数（SDI）的增加而增加。s 人类发展指数（HDI），全球不同国家的癌症特征各不相同。全球癌症负担持续增加，不同地区、年龄、国家、性别和癌症类型之间的死亡率和发病率存在显着差异。有效且因地制宜的癌症预防和控制措施对于减少未来的全球癌症负担至关重要。