A block to viral cell entry Crimean-Congo hemorrhagic fever virus is a tickborne virus that can cause severe disease and even death in humans. Disease occurrence is linked to the geographic range of the tick vector, and climate change may increase this range. Infection of host cells requires the fusion glycoprotein Gc, which is the main target of neutralizing antibodies. Mishra et al . build on previous work that identified a combination of two Gc-targeting antibodies that gave postexposure protection in an animal model. The authors determined the structure of the antigen-binding fragments of the two antibodies bound to a prefusion form of Gc and also the structure of Gc after the conformational change into the trimeric postfusion form. The structures show how the antibodies work together to block membrane fusion. —VV

中文翻译：

---

人抗体协同中和克里米亚-刚果出血热病毒的结构基础

阻止病毒进入细胞 克里米亚-刚果出血热病毒是一种蜱传病毒，可导致人类严重疾病甚至死亡。疾病的发生与蜱媒介的地理范围有关，气候变化可能会扩大这一范围。宿主细胞的感染需要融合糖蛋白Gc，它是中和抗体的主要靶标。米什拉等人. 基于之前的工作，确定了两种 Gc 靶向抗体的组合，可在动物模型中提供暴露后保护。作者确定了与融合前形式的 Gc 结合的两种抗体的抗原结合片段的结构，以及构象变化为三聚体融合后形式后的 Gc 结构。这些结构显示了抗体如何协同工作以阻断膜融合。—VV