Insufficient diuretic response frequently occurs in patients admitted for acute heart failure (HF) and is associated with worse clinical outcomes. Recent studies have shown that measuring natriuresis early after hospital admission could reliably identify patients with a poor diuretic response during hospitalization who might require enhanced diuretic treatment. This study will test the hypothesis that natriuresis-guided therapy in patients with acute HF improves natriuresis and clinical outcomes.

中文翻译：

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利尿钠引导治疗急性心力衰竭：急性心力衰竭 (PUSH-AHF) 试验中基于尿钠的实用化治疗算法的原理和设计

因急性心力衰竭 (HF) 入院的患者经常出现利尿剂反应不足，并与较差的临床结果相关。最近的研究表明，入院后早期测量尿钠排泄可以可靠地识别住院期间利尿剂反应不佳的患者，这些患者可能需要加强利尿剂治疗。本研究将检验急性心衰患者的尿钠排泄指导治疗改善尿钠排泄和临床结果的假设。