Development of a high intensity parallel photoreactor for high throughput screening,Reaction Chemistry & Engineering

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Development of a high intensity parallel photoreactor for high throughput screening
Reaction Chemistry & Engineering ( IF 3.4 ) Pub Date : 2021-11-17 , DOI: 10.1039/d1re00317h
Ning Qi ₁ , Michael K. Wismer ₂ , Donald V. Conway ₂ , Shane W. Krska ₁ , Spencer D. Dreher ₁ , Shishi Lin ₁

Affiliation

We report the development of a high intensity photoreactor that enables high throughput screening of up to 1536 reactions on nanomole scales in parallel. The increased photon flux provided by this new reactor compared to previous parallel reactor designs enables high performance for reactions that are sensitive to light intensity. In addition, the uniformity of illumination and efficient heat removal of this reactor allow for the systematic investigation of the complex interplay between parameters such as light intensity, catalyst loading and reaction stoichiometry on nanomole scale. The ability to run hundreds or thousands of unique photochemistry experiments under highly controlled conditions also provides a standardized platform for screening and data gathering for informatics. Finally, the reactor allows for the successful reproduction of screening hits at medicinal chemistry relevant scales.

中文翻译：

用于高通量筛选的高强度平行光反应器的开发

我们报告了一种高强度光反应器的开发，该反应器能够在纳摩尔级并行高通量筛选多达 1536 个反应。与以前的平行反应器设计相比，这种新反应器提供的光子通量增加，使对光强度敏感的反应具有高性能。此外，该反应器的照明均匀性和高效散热允许对光强度、催化剂负载和反应化学计量等参数之间复杂的相互作用进行系统研究。在高度受控的条件下运行数百或数千个独特的光化学实验的能力也为信息学的筛选和数据收集提供了一个标准化的平台。最后，

更新日期：2021-12-10

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