Dyslipidemia has recently been identified as an important factor in modulating the progression of several health conditions, grouped as cardio-metabolic syndrome and including obesity,insulin resistance, and atherosclerosis. Among multiple factors which regulate the development of cardio-metabolic syndrome, sortilin has been found in multiple cell types, such as adipocyte, hepatocyte, and macrophage, suggesting that sortilin is correlated to the development and the severity of cardio-metabolic syndrome. Consistently, several genome-wide association (GWAS) and basic experimental research studies are being conducted to find novel gene loci involved in regulating the pathological progression of cardio-metabolic syndrome. According to these data, both SORT1 gene and sortilin protein have an important function in regulating the circulating lipid and glucose metabolism resulting in modulation of disease progression. In this comprehensive review, we summarize the recent research results in regards to sortilin function in modulating the circulating lipid and glucose metabolism. Moreover, we also discuss and analyze the emerging evidence elucidating the potential mechanisms by which sortilin affects synthesis and secretion of lipid and glucose.

中文翻译：

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sortilin 在影响葡萄糖和脂质代谢的新作用。

血脂异常最近被确定为调节多种健康状况进展的重要因素，这些健康状况被归类为心脏代谢综合征，包括肥胖、胰岛素抵抗和动脉粥样硬化。在调节心脏代谢综合征发展的多种因素中，已在脂肪细胞、肝细胞和巨噬细胞等多种细胞类型中发现了 sortilin，这表明 sortilin 与心脏代谢综合征的发展和严重程度相关。一致地，正在进行几项全基因组关联 (GWAS) 和基础实验研究，以寻找参与调节心脏代谢综合征病理进展的新基因位点。根据这些数据，SORT1 基因和 sortilin 蛋白在调节循环脂质和葡萄糖代谢中均具有重要功能，从而调节疾病进展。在这篇综合综述中，我们总结了关于 sortilin 功能在调节循环脂质和葡萄糖代谢中的最新研究成果。此外，我们还讨论和分析了阐明 sortilin 影响脂质和葡萄糖合成和分泌的潜在机制的新证据。