Green & Sustainable Chemistry Social Cooperation Laboratory Graduate School of Science The University of Tokyo Hongo, Bunkyo-ku Tokyo 133-0033 Japan
Department of Chemistry School of Science The University of Tokyo Hongo, Bunkyo-ku Tokyo 113-0033 Japan
Research Institute of Chemical Process Technology National Institute of Advanced Industrial Science and Technology Nigatake 4-2-1 Sendai Miyagi 983-8551 Japan
Interdisciplinary Research Center for Catalytic Chemistry National Institute of Advanced Industrial Science and Technology Central 5, Higashi 1-1-1 Tsukuba Ibaraki 305-8565 Japan
The front cover picture, depicts Metalaxyl, an acylalanine fungicide, which was synthesized through catalytic continuous sequential-flow reactions. A halide-free approach including two continuous-flow catalytic processes, heterogeneous Pt-catalyzed reductive alkylation and homogeneous acid-catalyzed amidation with an acid anhydride, was developed to minimize waste and enhance efficiency. Systematic examination of the two reactions in flow mode enabled a high-yielding, two-step sequential continuous-flow process, achieving continuous synthesis of an agrochemical. Details can be found in the Communication by Shu Kobayashi and co-workers (H. Ishitani, Z. Yu, T. Ichitsuka, N. Koumura, S.-y. Onozawa, K. Sato, S. Kobayashi, Adv. Synth. Catal. 2022, 364, 18–23; DOI: 10.1002/adsc.202100898).
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