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Front Cover Picture: Two-Step Continuous-Flow Synthesis of Fungicide Metalaxyl through Catalytic C−N Bond-Formation Processes (Adv. Synth. Catal. 1/2022)
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2021-11-17 , DOI: 10.1002/adsc.202101328
H. Ishitani 1 , Z. Yu 2 , T. Ichitsuka 3, 4 , N. Koumura 4 , S‐y. Onozawa 4 , K. Sato 4 , S. Kobayashi 1, 2, 4
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The front cover picture, depicts Metalaxyl, an acylalanine fungicide, which was synthesized through catalytic continuous sequential-flow reactions. A halide-free approach including two continuous-flow catalytic processes, heterogeneous Pt-catalyzed reductive alkylation and homogeneous acid-catalyzed amidation with an acid anhydride, was developed to minimize waste and enhance efficiency. Systematic examination of the two reactions in flow mode enabled a high-yielding, two-step sequential continuous-flow process, achieving continuous synthesis of an agrochemical. Details can be found in the Communication by Shu Kobayashi and co-workers (H. Ishitani, Z. Yu, T. Ichitsuka, N. Koumura, S.-y. Onozawa, K. Sato, S. Kobayashi, Adv. Synth. Catal. 2022, 364, 18–23; DOI: 10.1002/adsc.202100898).
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中文翻译:

封面图片:通过催化 CN 键形成过程两步连续流合成杀菌剂甲霜灵 (Adv. Synth. Catal. 1/2022)

所述前盖的画面,示出了甲霜灵,酰基丙氨酸杀真菌剂,将其通过催化连续顺序流反应合成。开发了一种不含卤化物的方法,包括两个连续流动催化过程,多相铂催化还原烷基化和均相酸催化与酸酐的酰胺化,以最大限度地减少浪费并提高效率。在流动模式下对两个反应进行系统检查,实现了高产、两步连续连续流动过程,实现了农用化学品的连续合成。详细信息可以在 Shu Kobayashi 和同事(H. Ishitani、Z. Yu、T​​. Ichitsuka、N. Koumura、S.-y. Onozawa、K. Sato、S. Kobayashi、Adv. Synth.催化剂. 2022 , 364, 18–23; DOI:10.1002/adsc.202100898)。
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更新日期:2022-01-05
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