(±)-Cyclopeltains A and B (1 and 2), two pairs of unusual alkylated adenine derivatives, were isolated from the insect Cyclopelta parva and structurally characterized. 1 and 2 both possess a 6/5/7/5 ring system arising from the alkylation of N⁷ and N¹⁰ by a C₆ unit and the formation of a furan ring. A plausible biosynthetic pathway for 1 and 2 was proposed. Biological evaluation of the enantiomers of 1 and 2 revealed that (−)-1 and (+)-2 could inhibit the production of TNF-α and IL-6 and the expression of iNOS, COX-2, and p-NF-κB.

中文翻译：

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来自昆虫 Cyclopelta parva 的具有 6/5/7/5 环系统的烷基修饰的核碱基

(±)-Cyclopeltains A 和 B（1和2），两对不寻常的烷基化腺嘌呤衍生物，从昆虫Cyclopelta parva中分离出来并进行了结构表征。1和2都具有6/5/7/5环系统，由C ₆单元对N ⁷和N ¹⁰进行烷基化并形成呋喃环而产生。提出了1和2 的合理生物合成途径。1和2的对映异构体的生物学评估表明 (-)- 1和 (+)- 2可抑制TNF-α和IL-6的产生以及iNOS、COX-2和p -NF-κB的表达。