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New Heights for ProTides?
Journal of Medicinal Chemistry ( IF 6.8 ) Pub Date : 2021-11-16 , DOI: 10.1021/acs.jmedchem.1c01908
Carlo Ballatore 1
Affiliation  

In this issue of the Journal of Medicinal Chemistry, Janeba et al. found that the in vitro antiviral activity and selectivity index of the aryloxy phosphoramidate (ProTide) prodrug of the acyclic nucleoside phosphonate tenofovir (tenofovir alafenamide) can be dramatically improved by replacing the aryloxy pro-moiety with an appropriate tyrosine derivative. This Viewpoint highlights the possible impact and ramifications that these findings may have in the development of new ProTides.

中文翻译:

ProTides 的新高度?

在本期《药物化学杂志》中,Janeba 等人。发现无环核苷膦酸替诺福韦(tenofovir alafenamide)的芳氧基氨基磷酸酯(ProTide)前药的体外抗病毒活性和选择性指数可以通过用合适的酪氨酸衍生物代替芳氧基前体而显着提高。该观点强调了这些发现可能对新 ProTides 的开发产生的影响和后果。
更新日期:2021-11-25
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