Enabling Metallophotoredox Catalysis in Parallel Solution-Phase Synthesis Using Disintegrating Reagent Tablets,The Journal of Organic Chemistry

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Enabling Metallophotoredox Catalysis in Parallel Solution-Phase Synthesis Using Disintegrating Reagent Tablets
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2021-11-17 , DOI: 10.1021/acs.joc.1c01867
Niginia Borlinghaus ₁ , Barbara Schönfeld ₂ , Stephanie Heitz ₁ , Johanna Klee ₁ , Stella Vukelić ₁ , Wilfried M Braje ₁ , Anais Jolit ₁

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Compressed tablets containing a mixture of a photocatalyst, a nickel catalyst, an inorganic base, and an inert excipient are employed as a fast, safe, and user-friendly chemical delivery system for two different metallophotoredox-catalyzed reactions. This delivery method simplifies the preparation of compound libraries using photoredox chemistry in a parallel setting. The reagent tablets were successfully applied to late-stage functionalization of drug-like intermediates. These tablets can be prepared with various reagents and catalysts in different sizes and be stored on the bench thanks to blister packaging.

中文翻译：

使用崩解试剂片在平行溶液相合成中实现金属光氧化还原催化

含有光催化剂、镍催化剂、无机碱和惰性赋形剂混合物的压片被用作快速、安全和用户友好的化学递送系统，用于两种不同的金属光氧化还原催化反应。这种交付方法简化了在并行设置中使用光氧化还原化学制备化合物库。该试剂片成功应用于类药中间体的后期功能化。这些片剂可以用不同尺寸的各种试剂和催化剂制备，并通过泡罩包装储存在工作台上。

更新日期：2021-12-03

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