Optical Coherence Tomography (OCT) is a noninvasive, high-speed, high-resolution imaging technology based in the Michaelson interferometry. A near-infrared light beam is used to register the intensity variations for the light backscattered on each sample layer. Due to the high repeatability on corneal measurements, spectral domain OCT (SD-OCT) is the gold standard when talking about in vivo, non-invasive anterior segment imaging. Changes in the morphology of various ocular surfaces such as the cornea, conjunctiva, limbus or tear film with soft (SCL), rigid, corneal or scleral lens (SL) wear can be described by OCT measurements. For instance, evaluation of the corneoscleral region is essential on SL fitting. For orthokeratology lenses central epithelial thinning and peripheral thickening and their regression could be quantified with OCT after Ortho-K lens wear. Blood vessel compression on the landing zone as well as vault thickness and fluid reservoir (FR) turbidity could be imaged with OCT. Tear film evaluation on contact lens wearers is essential because its use could lead to variations on the biochemical components in tears. Changes in tear meniscus dynamics and several parameters such as volume (TMV), tear meniscus height (HMT) and turbidity could be determined with OCT and positively correlated with the instillation of different ophthalmic solutions with Non-Invasive Break Up Time (NIBUT) and Schirmer test values. This manuscript shows the increasing applicability of OCT technology for the in vivo characterization of contact lens fitting and interaction with the ocular surface in a faster, safer and non-invasive way. Future research will still allow exploring OCT imaging to its full potential in contact lens practice, as there is still a significant amount of information contained in the images that are not yet easy to extract, analyze and give clinical value.

光学相干断层扫描 (OCT) 是一种基于迈克尔逊干涉测量的无创、高速、高分辨率成像技术。近红外光束用于记录在每个样品层上反向散射的光的强度变化。由于角膜测量的高重复性，光谱域 OCT (SD-OCT) 是谈论体内非侵入性眼前节成像时的黄金标准。通过 OCT 测量可以描述各种眼表的形态变化，例如角膜、结膜、角膜缘或泪膜与软 (SCL)、刚性、角膜或巩膜透镜 (SL) 磨损。例如，角膜巩膜区域的评估对于 SL 拟合至关重要。对于角膜塑形镜镜片，中心上皮变薄和外周增厚以及它们的消退可以在 Ortho-K 镜片佩戴后用 OCT 进行量化。OCT 可以对着陆区的血管压缩以及穹窿厚度和储液器 (FR) 浊度进行成像。对隐形眼镜佩戴者进行泪膜评估至关重要，因为它的使用可能导致泪液中生化成分的变化。泪液半月板动力学的变化和诸如体积 (TMV)、泪液半月板高度 (HMT) 和浊度等参数的变化可以通过 OCT 确定，并且与具有非侵入性破裂时间 (NIBUT) 和 Schirmer 的不同滴眼液的滴注呈正相关测试值。这份手稿展示了 OCT 技术在体内表征隐形眼镜装配和以更快、更安全和无创的方式与眼表相互作用方面的应用日益增加。未来的研究仍将允许探索 OCT 成像在隐形眼镜实践中的全部潜力，因为图像中仍然包含大量信息，尚不易提取、分析和提供临床价值。