Designing a structure in nanoscale with desired shape and properties has been enabled by structural DNA nanotechnology. Design strategies in this research field have evolved to interpret various aspects of increasingly more complex nanoscale assembly and to realize molecular-level functionality by exploring static to dynamic characteristics of the target structure. Computational tools have naturally been of significant interest as they are essential to achieve a fine control over both shape and physicochemical properties of the structure. Here, we review the basic design principles of structural DNA nanotechnology together with its computational analysis and design tools.

中文翻译：

---

DNA 纳米结构的设计方法和计算工具


结构 DNA 纳米技术已经能够设计具有所需形状和特性的纳米级结构。该研究领域的设计策略已经发展到解释日益复杂的纳米级组装的各个方面，并通过探索目标结构的静态到动态特性来实现分子级功能。计算工具自然引起了人们的极大兴趣，因为它们对于实现结构形状和物理化学性质的精细控制至关重要。在这里，我们回顾了结构 DNA 纳米技术的基本设计原理及其计算分析和设计工具。