Purpose

Nasal screening is performed to avoid the complications of postoperative surgical site infections (SSI), especially those due to antimicrobial-resistant species such as methicillin-resistant Staphylococcus aureus (MRSA). This study examined the relationship between bacterial isolates from the conjunctiva and the nasal cavity.

Methods

All patients were diagnosed with ocular surface infections, and the organisms in the conjunctiva and the nasal cavity were isolated. We investigated the relationship of the following antimicrobial-resistant bacteria between the conjunctiva and the nose: MRSA, methicillin-resistant CNS (MRCNS), levofloxacin-resistant (LVFX-R) Corynebacterium spp. Data were analyzed using Fisher’s exact test, and the odds ratio was examined.

Results

This study included 188 eyes of 188 subjects (87 males and 101 females; mean age 58.5 years, range 11–97 years). MRSA (4 eyes), MRCNS (29 eyes), and LVFX-R Corynebacterium spp. (41 eyes) were identified from the conjunctiva, and MRSA (6 eyes), MRCNS (38 eyes), and LVFX-R Corynebacterium spp. (41 eyes) were identified from the nasal cavity. There was a significant relationship detected between the conjunctiva and the nose for MRSA, MRCNS, and LVFX-R Corynebacterium spp. MRSA displayed high sensitivity (0.750, 95% confidence interval [CI]; 0.301 to 0.987) and specificity (0.984, 95% CI; 0.953 to 0.996) in nasal cavity cultures, and the odds ratio was 181.00 times (95% CI; 18.41 to 2320).

Conclusion

This study showed a significant relationship between conjunctival and nasal cultures of MRSA, MRCNS, and LVFX-R Corynebacterium spp., suggesting that nasal cavity culture is a potentially useful screening method for detecting resistant bacteria, especially MRSA, in the conjunctiva.

中文翻译：

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耐甲氧西林金黄色葡萄球菌鼻和结膜培养物的关系

目的

进行鼻部筛查是为了避免术后手术部位感染 (SSI) 的并发症，尤其是由耐甲氧西林金黄色葡萄球菌(MRSA) 等耐药菌引起的并发症。这项研究检查了结膜和鼻腔的细菌分离物之间的关系。

方法

所有患者均被诊断为眼表感染，结膜和鼻腔内的微生物均被分离出来。我们调查了结膜和鼻子之间以下耐药细菌的关系：MRSA、耐甲氧西林中枢神经系统 (MRCNS)、耐左氧氟沙星 (LVFX-R)棒状杆菌属。使用Fisher精确检验分析数据，并检查优势比。

结果

这项研究包括 188 名受试者的 188 只眼睛（87 名男性和 101 名女性；平均年龄 58.5 岁，范围 11-97 岁）。MRSA（4 眼）、MRCNS（29 眼）和 LVFX-R棒状杆菌属。（41 只眼）从结膜、MRSA（6 只眼）、MRCNS（38 只眼）和 LVFX-R棒状杆菌属中鉴定出。（41只眼睛）从鼻腔中识别出来。在结膜和鼻子之间检测到 MRSA、MRCNS 和 LVFX-R棒状杆菌属的显着相关性。MRSA 在鼻腔培养中表现出高敏感性（0.750, 95% CI; 0.301 to 0.987）和特异性（0.984, 95% CI; 0.953 to 0.996），优势比为181.00倍（95% CI; 18.41）到 2320)。

结论

该研究表明 MRSA、MRCNS 和 LVFX-R棒状杆菌属的结膜和鼻腔培养物之间存在显着关系，这表明鼻腔培养物是一种潜在有用的筛查方法，可用于检测结膜中的耐药菌，尤其是 MRSA。