Abstract

Purpose

To determine the retinal vessel diameter changes after angiotensin-converting enzyme (ACE) inhibitor treatment in a group of hypertensive patients.

Methods

This study included 60 treatment-naive hypertensive patients who were treated with ACE inhibitor. Sixty healthy volunteers served as control group. An optical coherence tomography scan protocol including the measurement of peripapillary retinal vessel diameters was performed at baseline and at 1st month. The diameters of superior temporal artery (STA), inferior temporal artery (ITA), superior temporal vein (STV), inferior temporal vein (ITV), superior nasal artery (SNA), inferior nasal artery (INA), superior nasal vein (SNV) and inferior nasal vein (INV) were statistically compared.

Results

The baseline diameters of the STA, ITA, SNA, and INA were significantly decreased in the patient group compared with the control group (all p < 0.05). There was a significant increase at 1st month after the treatment in comparison to baseline measurements (all p < 0.05). When compared with the controls, only the diameter of SNV showed a significant decrease at baseline (p = 0.031). After the treatment, the diameters of SNV and INV were significantly increased compared with baseline measurements (p = 0.049 and p = 0.035, respectively). There were no significant differences between the control group and the patient group at 1st month (all p > 0.05).

Conclusion

Short-term treatment with ACE inhibitor led to a significant improvement in the retinal vessel diameters of patients with hypertension.

中文翻译：

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血管紧张素转换酶抑制剂对系统性高血压患者视网膜血管直径的短期影响

摘要

目的

确定一组高血压患者血管紧张素转换酶 (ACE) 抑制剂治疗后视网膜血管直径的变化。

方法

该研究包括 60 名接受过 ACE 抑制剂治疗的初治高血压患者。60名健康志愿者作为对照组。在基线和第 1 个月进行光学相干断层扫描协议，包括测量视盘周围视网膜血管直径。颞上动脉（STA）、颞下动脉（ITA）、颞上静脉（STV）、颞下静脉（ITV）、鼻上动脉（SNA）、鼻下动脉（INA）、鼻上静脉（SNV）的直径) 和下鼻静脉 (INV) 进行了统计学比较。

结果

与对照组相比，患者组的 STA、ITA、SNA 和 INA 基线直径显着降低（均p  < 0.05）。与基线测量值相比，治疗后第 1 个月显着增加（均p  < 0.05）。与对照组相比，只有 SNV 的直径在基线时显示出显着减小（p  = 0.031）。治疗后，与基线测量值相比，SNV 和 INV 的直径显着增加（分别为p  = 0.049 和p  = 0.035）。1个月时对照组与患者组无显着差异（均p  >0.05）。

结论

ACE 抑制剂的短期治疗可显着改善高血压患者的视网膜血管直径。