To describe incidence of foot ulceration and amputation-free survival associated with foot ulceration status in a national population-based cohort study of people with diabetes.

The study population included 233,459 people with diabetes who were alive in Scotland on 1 January 2012 identified from the national population-based register (national prevalence 4.9%). Characteristics of patients identified from linked hospital and mortality records during follow-up to the end of November 2017 were compared by outcome. Cox regression was used to assess the association between history of foot ulcer and amputation-free survival.

The population included 23,395 people with type 1 diabetes and 210,064 people with type 2 diabetes. In total there were 13,093 (5.6%) people who had a previous foot ulceration, 9,023 people who developed a first ulcer, 48,995 who died, and 2,866 who underwent minor or major amputation during follow-up. Overall incidence of first-time foot ulcers was 7.8 per 1,000 person-years (95% CI7.6–7.9) and 11.2 (11.0–11.4) for any ulcer. Risk factors for reduced amputation-free survival included social deprivation, mental illness, and being underweight in addition to conventional cardiovascular risk factors. Adjusted hazard ratios (95% CI) were 2.09 (1.89–2.31) for type 1 diabetes and 1.65 (1.60–1.70) for type 2 diabetes.

The overall incidence of foot ulceration in a population-based study of people with diabetes was 11.2 per 1,000 person-years. Foot ulceration is associated with lower amputation-free survival rate, a potential measure of effectiveness of care among people with diabetes. Mental illness and social deprivation are also highlighted as risk factors.

在一项针对糖尿病患者的全国人群队列研究中，描述与足部溃疡状态相关的足部溃疡发生率和无截肢生存率。

研究人群包括 2012 年 1 月 1 日在苏格兰活着的 233,459 名糖尿病患者，这些糖尿病患者来自全国人口登记册（全国患病率 4.9%）。对截至 2017 年 11 月的随访期间从相关医院和死亡率记录中确定的患者特征进行了比较。Cox 回归用于评估足部溃疡病史与无截肢生存率之间的关联。

该人群包括 23,395 名 1 型糖尿病患者和 210,064 名 2 型糖尿病患者。总共有 13,093 人（5.6%）曾有足部溃疡，9,023 人首次出现溃疡，48,995 人死亡，2,866 人在随访期间接受了小截肢或大截肢。首次足部溃疡的总发病率为 7.8/1,000 人年 (95% CI7.6–7.9) 和任何溃疡的 11.2 (11.0–11.4)。除了传统的心血管风险因素外，无截肢生存率降低的风险因素还包括社会剥夺、精神疾病和体重不足。1 型糖尿病的调整后风险比 (95% CI) 为 2.09 (1.89-2.31)，2 型糖尿病为 1.65 (1.60-1.70)。

在一项基于人群的糖尿病患者研究中，足部溃疡的总发病率为 11.2/1000 人年。足部溃疡与较低的无截肢生存率相关，这是衡量糖尿病患者护理有效性的潜在指标。精神疾病和社会剥夺也被强调为危险因素。