Purpose: 

To compare the endothelial quality of corneas obtained from pseudophakic donors with age-matched phakic controls.

Methods: 

Retrospective analysis of 100 corneas each from pseudophakic and phakic eyes with donor age ≥60 years in both the groups was performed. The endothelial cell density, coefficient of variation, and percentage of hexagonal cells obtained by specular microscopy were compared between the two groups. The cut-off level of endothelial cell density (ECD) taken for optical keratoplasty was 2,000 cells/mm².

Results: 

The male and female donors constituted 60% (n=120) and 40% (n=80), respectively. The mean age of the donors was 66.9±7.3 years in the phakic group and 69.9±7.7 years in pseudophakic group. The mean ECD in the phakic group was 2757.6±328.5 cells/mm² and that in the pseudophakic group was 2225.5±471.9 cells/mm² (P<0.0001). The mean coefficient of variation in the phakic group was 37.1±5.0 and that in the pseudophakic group was 38.6±11.1 (P=0.234). The mean percentage of hexagonality in the phakic group and the pseudophakic group was 52.0±6.4% and 51.2±7.2%, respectively (P=0.414). Both in univariate and multivariate linear regression analysis, age of the donor was found to be negatively associated in predicting ECD (P=0.002 and P=0.003, respectively). Sixty-nine and thirty-three corneas from the phakic and pseudophakic donor pool were used respectively.

Conclusion: 

Difference in ECD between the phakic and the pseudophakic donor group was found to be statistically significant. The ECD in the pseudophakic group was found to be above the cut-off limit required for keratoplasty. Hence, pseudophakic corneas may also be used for transplantation.

中文翻译：

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假晶状体和有晶状体供体角膜组织特征的比较

目的： 

比较从人工晶状体供体获得的角膜内皮质量与年龄匹配的晶状体对照。

方法： 

对两组供体年龄≥60岁的人工晶状体和有晶状体眼各100个角膜进行回顾性分析。比较两组的内皮细胞密度、变异系数和镜面显微镜下六角形细胞的百分比。用于光学角膜移植术的内皮细胞密度 (ECD) 的截止水平为 2,000 个细胞/mm ²。

结果： 

男性和女性捐赠者分别占 60% (n=120) 和 40% (n=80)。有晶状体组供体的平均年龄为66.9±7.3岁，人工晶状体组为69.9±7.7岁。晶状体组平均ECD为2757.6±328.5个细胞/mm ²，人工晶状体组为2225.5±471.9个细胞/mm ²（P <0.0001）。晶状体组平均变异系数为37.1±5.0，人工晶状体组为38.6±11.1（P =0.234）。晶状体组和假晶状体组的平均六角形百分比分别为52.0±6.4%和51.2±7.2%（P=0.414）。在单变量和多变量线性回归分析中，发现供体年龄与预测 ECD 呈负相关（分别为P = 0.002 和P = 0.003）。分别使用了来自有晶状体和假晶状体供体库的 69 个和 33 个角膜。

结论： 

发现有晶状体和假晶状体供体组之间ECD的差异具有统计学意义。发现人工晶状体组中的 ECD 高于角膜移植术所需的临界值。因此，人工晶状体角膜也可用于移植。