Human brain networks undergo pronounced changes during development. The emergence of highly connected hub regions that can support integrated brain function is central to this maturational process, with these areas undergoing a particularly protracted period of development that extends into adulthood. The location of cortical network hubs emerges early but connections to and from hubs continue to strengthen throughout childhood and adolescence. Patterns of functional coupling in cortical association hubs are immature and incomplete at birth, but gradually strengthen during development. Early establishment of hub connectivity may provide a stable substrate that is refined by changes in tissue organization and microstructure, resulting in the emergence of complex functional dynamics by adulthood.

人脑网络在发育过程中经历了显着的变化。可以支持综合大脑功能的高度连接的枢纽区域的出现是这一成熟过程的核心，这些区域经历了一个特别漫长的发展时期，一直延伸到成年期。皮层网络枢纽的位置很早就出现了，但在整个童年和青春期，与枢纽的联系不断加强。皮质关联中心的功能耦合模式在出生时不成熟且不完整，但在发育过程中逐渐增强。中枢连接的早期建立可以提供一个稳定的基质，通过组织组织和微观结构的变化来完善，导致成年后出现复杂的功能动力学。