Synthesis and Applications of Organic Selenols,Advanced Synthesis & Catalysis

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Synthesis and Applications of Organic Selenols
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2021-11-12 , DOI: 10.1002/adsc.202101147
Damiano Tanini ₁ , Antonella Capperucci ₁

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The synthesis and the study of organoselenium compounds have received much attention over the past decades. Selenium-containing organic molecules are widely used in organic synthesis, materials science, and medicinal chemistry. Selenium – and more specifically the amino acid selenocysteine, bearing a selenol (SeH) moiety – is present in at least 25 human protein families, whose biological functions have not been completely identified. Amongst the variety of organoselenium compounds, selenols are a versatile class of molecules easily undergoing a broad array of useful transformations. Because of the unique properties of the SeH group, selenol chemistry has important applications in chemical sciences, spanning from organic synthesis to materials chemistry and biology. This review summarises currently available methodologies for the synthesis of selenols and highlights applications of selenols in chemical sciences and biology.

中文翻译：

有机硒醇的合成与应用

在过去的几十年里，有机硒化合物的合成和研究受到了广泛关注。含硒有机分子广泛用于有机合成、材料科学和药物化学。硒——更具体地说是带有硒醇 (SeH) 部分的氨基酸硒代半胱氨酸——存在于至少 25 个人类蛋白质家族中，其生物学功能尚未完全确定。在各种有机硒化合物中，硒醇是一类通用的分子，很容易进行各种有用的转化。由于 SeH 基团的独特性质，硒醇化学在化学科学中有着重要的应用，从有机合成到材料化学和生物学。

更新日期：2021-12-21

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