Purpose

The performance of ⁶⁸ Ga-PSMA PET/CT-MR has been evaluated in prostate cancer (PCa), showing significant results. However, even a technically accurate imaging procedure requires a high interobserver agreement in its interpretation to implement in patients’ management. This study aims to perform a systematic review and meta-analysis on the interobserver variability in ⁶⁸ Ga-PSMA PET/CT-MR imaging in PCa patients.

Methods

We conducted a systematic review and meta-analysis on the interobserver variability, including studies: (1) providing Kappa (K) as the inter-observer agreement test or the essential data to calculate it, (2) providing the K confidence interval or the essential crude data to calculate it, (3) measuring K statistic based on the appropriate use criteria for the inter-observer agreement.

Results

Twelve studies, providing 1585 ⁶⁸ Ga-PSMA PET/CT-MR studies reviewed by 62 independent readers, were included. In general, the pooled inter-observer agreement was interpreted as substantial for all analyzed groups, including tumoral lesions in the prostate bed, lymphadenopathies, bone metastasis, and soft-tissue metastasis (all between 0.6 and 0.8). The regional lymphadenopathy group (0.74) obtained the highest agreement, while the lowest was for soft tissue metastasis (0.65).

Conclusion

This study showed a substantial interobserver agreement in the overall interpretation and detecting locoregional and distant involvement with ⁶⁸ Ga-PSMA PET/CT-MR in PCa patients.

中文翻译：

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68Ga-PSMA PET 在前列腺癌中的应用：观察者协议的系统评价和荟萃分析

目的

⁶⁸ Ga-PSMA PET/CT-MR的性能 已在前列腺癌 (PCa) 中进行了评估，显示出显着的效果。然而，即使是技术上准确的成像程序，也需要观察者间高度一致的解释才能在患者管理中实施。 本研究旨在对PCa 患者⁶⁸ Ga-PSMA PET/CT-MR 成像的观察者间变异性进行系统回顾和荟萃分析。

方法

我们对观察者间变异性进行了系统回顾和荟萃分析，包括研究：（1）提供 Kappa（K）作为观察者间一致性检验或计算它的基本数据，（2）提供 K 置信区间或计算它的基本原始数据，(3) 根据观察者间协议的适当使用标准测量 K 统计量。

结果

包括12 项研究，提供 1585 ⁶⁸  Ga-PSMA PET/CT-MR 研究，由 62 位独立读者审查。一般来说，对于所有分析组，汇总的观察者间一致性被解释为实质性，包括前列腺床的肿瘤病变、淋巴结病、骨转移和软组织转移（均在 0.6 和 0.8 之间）。区域淋巴结肿大组（0.74）的一致性最高，而软组织转移的一致性最低（0.65）。

结论

^{这项研究表明， 68}  Ga-PSMA PET/CT-MR 在 PCa 患者中的整体解释和检测局部和远处受累方面具有实质性的观察者间协议。