Pacific Ocean rockfishes (genus Sebastes) exhibit extreme variation in life span, with some species being among the most long-lived extant vertebrates. We de novo assembled the genomes of 88 rockfish species and from these identified repeated signatures of positive selection in DNA repair pathways in long-lived taxa and 137 longevity-associated genes with direct effects on life span through insulin signaling and with pleiotropic effects through size and environmental adaptations. A genome-wide screen of structural variation reveals copy number expansions in the immune modulatory butyrophilin gene family in long-lived species. The evolution of different rockfish life histories is coupled to genetic diversity and reshapes the mutational spectrum driving segregating CpG→TpG variants in long-lived species. These analyses highlight the genetic innovations that underlie life history trait adaptations and, in turn, how they shape genomic diversity.

中文翻译：

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太平洋石斑鱼极端寿命的起源和进化


太平洋石斑鱼（ Sebastes属）的寿命差异极大，其中一些物种是现存脊椎动物中最长寿的。我们从头组装了 88 个石斑鱼物种的基因组，并从中识别出长寿类群 DNA 修复途径中正选择的重复特征和 137 个长寿相关基因，这些基因通过胰岛素信号传导直接影响寿命，并通过大小和大小产生多效性效应。环境适应。全基因组结构变异筛选揭示了长寿物种中免疫调节嗜丁蛋白基因家族的拷贝数扩展。不同石斑鱼生命史的进化与遗传多样性相关，并重塑了长寿物种中驱动 CpG→TpG 变异分离的突变谱。这些分析强调了生命史性状适应背后的遗传创新，以及它们如何塑造基因组多样性。