Objectives

To investigate the associations between different single-piece monofocal intraocular lenses (IOLs) and neodymium-doped yttrium aluminum garnet laser (Nd:YAG) capsulotomy incidence 3 years after cataract surgery in a Spanish cohort.

Methods

This is a longitudinal retrospective cohort study. Data were extracted from the electronic medical records of two large regional hospitals in Spain. Patients aged ≥65 years receiving cataract surgery with placement of five different IOLs and with ≥6 months of baseline data were included. We report the Nd:YAG capsulotomy incidence 3 years post cataract surgery, and the survival plot over the 3 years of follow-up time. The associated adjusted (age, gender, and diabetic retinopathy) multivariate analysis with odds ratios (ORs) and 95% CIs is also presented.

Results

The cohort (53% female, mean age 75 ± 5.9 years) included 14,519 eyes (Alcon AcrySof = 2968, AJL LLASY60 = 1776, Medicontur Bi-flex = 5176, Zeiss Asphina = 4478, and IOL Tech Stabibag = 121). Of these, 8293 were retained until 3-year follow-up. At 3 years after cataract surgery, the Nd:YAG capsulotomy incidence was 5% for Alcon AcrySof, while it ranged from 21.2% to 31.1% for the other IOLs (p < 0.0001 for each comparison). The odds for Nd:YAG capsulotomy were significantly higher (p < 0.0001) for other IOLs compared with those of Alcon AcrySof (ORs = 8.85, 5.86, 5.74, 5.21 for AJL LLASY60, Medicontur Bi-flex, IOL Tech Stabibag, and Zeiss Asphina, respectively).

Conclusions

The lower Nd:YAG capsulotomy rates for Alcon AcrySof IOLs compared to the other IOLs support the importance of lens choice in reducing patient burden and treatment costs.

中文翻译：

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与五种不同的单片单焦点人工晶状体相关的 Nd:YAG 囊切开术发生率：一项针对 8293 只眼的为期 3 年的西班牙真实世界证据研究

目标

调查西班牙队列白内障手术后 3 年不同单片单焦点人工晶状体 (IOL) 和掺钕钇铝石榴石激光 (Nd:YAG) 囊切开术发生率之间的关联。

方法

这是一项纵向回顾性队列研究。数据是从西班牙两家大型地区医院的电子病历中提取的。年龄≥65 岁接受白内障手术并植入五种不同 IOL 且基线数据≥6 个月的患者被纳入。我们报告了白内障手术后 3 年的 Nd:YAG 囊切开术发生率，以及 3 年随访时间的生存图。还提供了具有比值比 (OR) 和 95% CI 的相关调整后（年龄、性别和糖尿病性视网膜病变）多变量分析。

结果

该队列（53% 为女性，平均年龄 75 ± 5.9 岁）包括 14,519 只眼（Alcon AcrySof = 2968、AJL LLASY60 = 1776、Medicontur Bi-flex = 5176、Zeiss Asphina = 4478 和 IOL Tech Stabibag = 121）。其中，8293 人保留到 3 年随访。白内障手术后 3 年，Alcon AcrySof 的 Nd:YAG 囊切开术发生率为 5%，而其他 IOL 的发生率为 21.2% 至 31.1%（ 每次比较的p < 0.0001）。 与 Alcon AcrySof（AJL LLASY60、Medicontur Bi-flex、IOL Tech Stabibag 和 Zeiss Asphina 的 ORs = 8.85、5.86、5.74、5.21）相比，其他 IOL的 Nd:YAG 囊切开术的几率显着更高 ( p < 0.0001) ， 分别）。

结论

与其他 IOL 相比，Alcon AcrySof IOL 的 Nd:YAG 囊切开率较低，这支持了镜片选择在减轻患者负担和治疗成本方面的重要性。