Transportation noise exposure and cardiovascular mortality: 15-years of follow-up in a nationwide prospective cohort in Switzerland,Environment International

当前位置： X-MOL 学术 › Environ. Int. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Transportation noise exposure and cardiovascular mortality: 15-years of follow-up in a nationwide prospective cohort in Switzerland
Environment International ( IF 10.3 ) Pub Date : 2021-11-11 , DOI: 10.1016/j.envint.2021.106974
Danielle Vienneau ₁ , Apolline Saucy ₂ , Beat Schäffer ₃ , Benjamin Flückiger ₁ , Louise Tangermann ₁ , Massimo Stafoggia ₄ , Jean Marc Wunderli ₃ , Martin Röösli ₁ ,

Affiliation

Background

Death from cardiovascular diseases (CVD) has been associated with transportation noise. This nationwide cohort, with state-of-the-art exposure assessment, evaluates these associations by noise source.

Methods

Road traffic, railway and aircraft noise for 2001 and 2011 were linked to 4.1 million adults in the Swiss National Cohort, accounting for address history. Mean noise exposure in 5-year periods was calculated. Time-varying Cox regression models, with age as timescale, were applied to all and cause-specific cardiovascular causes of death. Models included all three noise sources plus PM_2.5, adjusted for individual and spatial covariates. Nighttime noise events for all sources combined (expressed as intermittency ratio or number of events) were considered in sensitivity analyses. Absolute excess risk was calculated by multiplying deaths/100,000 person-years by the excess risk (hazard ratio-1) within each age/sex group.

Results

During a 15-year follow-up, there were 277,506 CVD and 34,200 myocardial infarction (MI) deaths. Associations (hazard ratio; 95%-CIs) for road traffic, railway and aircraft noise and CVD mortality were 1.029 (1.024–1.034), 1.013 (1.010–1.017), and 1.003 (0.996–1.010) per 10 dB L_den, respectively. Associations for MI mortality were a respective 1.043 (1.029–1.058), 1.020 (1.010–1.030) and 1.040 (1.020–1.060) per 10 dB L_den. Blood pressure-related, ischemic heart disease, and all stroke mortality were significantly associated with road traffic and railway noise, while ischemic stroke mortality was associated with aircraft noise. Associations were mostly linear, often starting below 40 dB L_den for road traffic and railway noise. Higher levels of noise intermittency were also independently associated with each outcome. While the absolute number of deaths attributed to noise increased with age, the hazard ratios declined with age. Relative and absolute risk was higher in males compared to females.

Conclusion

Independent of air pollution, transportation noise exposure is associated with all and cause-specific CVD mortality, with effects starting below current guideline limits.

中文翻译：

交通噪声暴露和心血管死亡率：瑞士全国前瞻性队列的 15 年随访

背景

心血管疾病（CVD）导致的死亡与交通噪音有关。这个全国性的队列采用最先进的暴露评估，通过噪声源评估这些关联。

方法

2001 年和 2011 年的道路交通、铁路和飞机噪音与瑞士国家队列中的 410 万成年人有关，占地址历史。计算了 5 年期间的平均噪声暴露量。以年龄为时间尺度的时变 Cox 回归模型适用于所有和特定原因的心血管死亡原因。模型包括所有三个噪声源和 PM _2.5，针对个体和空间协变量进行了调整。在敏感性分析中考虑了所有组合来源的夜间噪声事件（表示为间歇性比率或事件数）。绝对超额风险的计算方法是将死亡人数/100,000 人年乘以每个年龄/性别组内的超额风险（风险比-1）。

结果

在 15 年的随访中，有 277,506 例 CVD 和 34,200 例心肌梗塞 (MI) 死亡。道路交通、铁路和飞机噪声以及 CVD 死亡率的关联（风险比；95%-CI）分别为每 10 dB L _den 1.029 (1.024–1.034)、1.013 (1.010–1.017) 和 1.003 (0.996–1.010) . MI 死亡率的相关性分别为 1.043 (1.029–1.058)、1.020 (1.010–1.030) 和 1.040 (1.020–1.060) 每 10 dB L _den。血压相关、缺血性心脏病和所有卒中死亡率与道路交通和铁路噪声显着相关，而缺血性卒中死亡率与飞机噪声相关。关联大多是线性的，通常开始低于 40 dB L _den用于道路交通和铁路噪音。更高水平的噪音间歇性也与每个结果独立相关。虽然归因于噪音的绝对死亡人数随着年龄的增长而增加，但风险比随着年龄的增长而下降。与女性相比，男性的相对和绝对风险更高。