An efficient enantioselective [3 + 2] annulation of α-hydroxy-1-indanones and alkylidene azlactones has been developed with chiral dinuclear zinc catalysts via a Brønsted base and Lewis acid cooperative activation model. This practical methodology gives access to a broad range of chiral α-amino-γ-butyrolactones bearing three stereocenters in good yields with excellent diastereo- and enatiostereoselectivities (up to 88% yield, 20 : 1 dr, 99% ee). This transformation features broad functional group tolerance, gram-scale synthesis, and further prolongation with α-hydroxyacetophenone or 3-hydroxychroman-4-one.

中文翻译：

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双核锌催化不对称 [3 + 2] 环化反应，用于直接组装带有三个立体中心的手性 α-氨基-γ-丁内酯

通过布朗斯台德碱和路易斯酸协同活化模型，使用手性双核锌催化剂开发了 α-羟基-1-茚满酮和亚烷基吖内酯的有效对映选择性 [3 + 2] 环化。这种实用的方法可以获得范围广泛的具有三个立体中心的手性 α-氨基-γ-丁内酯，收率良好，具有出色的非对映选择性和对映立体选择性（收率高达 88%，20:1 dr，99% ee）。这种转化具有广泛的官能团耐受性、克级合成以及与 α-羟基苯乙酮或 3-羟基色满-4-one 的进一步延长。