Access to azonanes via Pd-catalyzed decarboxylative [5 + 4] cycloaddition with exclusive regioselectivity,Organic Chemistry Frontiers

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Access to azonanes via Pd-catalyzed decarboxylative [5 + 4] cycloaddition with exclusive regioselectivity
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2021-10-30 , DOI: 10.1039/d1qo01405f
Yin Liu _{1,

2} , Yicheng He ₂ , Yang Liu ₂ , Kun Wei ₁ , Wusheng Guo _{2,

3}

Affiliation

A highly efficient approach for the synthesis of azonanes via Pd-catalyzed decarboxylative [5 + 4] cycloaddition has been developed. This procedure utilizes methylene cyclic carbonates as a C5-dipole and 1-azadiene as a C4-synthon. The reactions could be performed at room temperature. The protocol features wide functional group tolerance with exclusive regioselectivity and generates CO₂ as the only byproduct.

中文翻译：

通过具有独特区域选择性的 Pd 催化脱羧 [5 + 4] 环加成反应获得氮烷

已经开发了一种通过Pd 催化脱羧 [5 + 4] 环加成合成氮烷的高效方法。该程序使用亚甲基环状碳酸酯作为 C5-偶极子和 1-氮杂二烯作为 C4-合成子。反应可以在室温下进行。该协议具有广泛的官能团耐受性和独特的区域选择性，并产生 CO ₂作为唯一的副产品。

更新日期：2021-11-11

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