PURPOSE To evaluate metabolic alterations along with the carcinoma ex pleomorphic adneoma (CXPA) development of lacrimal glands (LG). METHODS Four samples of the normal LG (NLG), 9 of pleomorphic adenoma (PA), 4 of residual PA (rPA), and 4 of CXPA of LG were included. GLUT-1, HIF-1α, FASN, and adipophilin by immunohistochemical stains were performed in the selected cases. RESULTS Was observed higher expression of markers associated with glycolytic and lipid metabolism in the tumor tissue samples when compared to the NLG samples. Additionally, GLUT-1, FASN, and Adipophilin were more expressed in CXPA samples while HIF-1α in PA samples. CONCLUSIONS In conclusion, our results demonstrate overexpression of FASN and Adipophilin in CXPA which may reflect a metabolic shift toward lipogenesis in cancer cells.

中文翻译：

---

泪腺癌前多形性腺瘤发展的代谢改变。

目的 评估代谢改变以及泪腺 (LG) 的多形性腺瘤 (CXPA) 发展。方法 包括4例正常LG（NLG）、9例多形性腺瘤（PA）、4例残余PA（rPA）和4例LG CXPA。在选定的病例中进行了免疫组织化学染色的 GLUT-1、HIF-1α、FASN 和 adipophilin。结果 与 NLG 样品相比，在肿瘤组织样品中观察到与糖酵解和脂质代谢相关的标志物的表达更高。此外，GLUT-1、FASN 和 Adipophilin 在 CXPA 样品中表达更多，而 HIF-1α 在 PA 样品中表达。结论 总之，我们的结果表明 CXPA 中 FASN 和 Adipophilin 的过表达，这可能反映了癌细胞中向脂肪生成的代谢转变。