Outpatient treatment for the worsening of signs and symptoms of heart failure (HF) is usually not incorporated in the main outcomes of HF trials. Patients with HF and a preserved ejection fraction (HFpEF) may experience frequent episodes of outpatient worsening HF. The aim of this study was to evaluate the frequency, prognostic impact, and the effect of spironolactone on outpatient diuretic intensification (ODI), among 1767 patients enrolled in TOPCAT-Americas.

中文翻译：

---

门诊利尿剂强化作为保留射血分数试验的心力衰竭终点：来自 TOPCAT 的分析

心力衰竭 (HF) 体征和症状恶化的门诊治疗通常不包含在 HF 试验的主要结果中。患有 HF 和保留射血分数 (HFpEF) 的患者可能会频繁出现门诊恶化的 HF。本研究的目的是评估在 TOPCAT-Americas 入组的 1767 名患者中，螺内酯对门诊利尿剂强化 (ODI) 的频率、预后影响和影响。