Atypical microbial keratitis refers to corneal infections caused by micro-organisms not commonly encountered in clinical practice. Unlike infections caused by common bacteria, cases of atypical microbial keratitis are often associated with worse clinical outcomes and visual prognosis. This is due to the challenges in the identification of causative organisms with standard diagnostic techniques, resulting in delays in the initiation of appropriate therapies. Furthermore, due to the comparatively lower incidence of atypical microbial keratitis, there is limited literature on effective management strategies for some of these difficult to manage corneal infections. This review highlights the current management and available evidence of atypical microbial keratitis, focusing on atypical mycobacteria keratitis, nocardia keratitis, achromobacter keratitis, and pythium keratitis. It will also describe the management of two uncommonly encountered conditions, infectious crystalline keratopathy and post-refractive infectious keratitis. This review can be used as a guide for clinicians managing patients with such challenging corneal infections.

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非典型微生物性角膜炎


非典型微生物性角膜炎是指由临床上不常见的微生物引起的角膜感染。与常见细菌引起的感染不同，非典型微生物性角膜炎病例通常与较差的临床结果和视力预后相关。这是由于用标准诊断技术识别致病微生物存在挑战，导致适当治疗的启动延迟。此外，由于非典型微生物性角膜炎的发病率相对较低，因此关于某些难以治疗的角膜感染的有效治疗策略的文献有限。本综述重点介绍了非典型微生物角膜炎的当前治疗方法和现有证据，重点关注非典型分枝杆菌角膜炎、诺卡氏菌角膜炎、无色杆菌角膜炎和腐霉角膜炎。它还将描述两种不常见情况的治疗，即传染性结晶性角膜病和屈光后传染性角膜炎。本综述可以作为临床医生处理此类具有挑战性的角膜感染患者的指南。