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An online GPCR structure analysis platform
Nature Structural & Molecular Biology ( IF 12.5 ) Pub Date : 2021-11-10 , DOI: 10.1038/s41594-021-00675-6
Albert J Kooistra 1 , Christian Munk 1, 2 , Alexander S Hauser 1 , David E Gloriam 1
Affiliation  

We present an online, interactive platform for comparative analysis of all available G-protein coupled receptor (GPCR) structures while correlating to functional data. The comprehensive platform encompasses structure similarity, secondary structure, protein backbone packing and movement, residue–residue contact networks, amino acid properties and prospective design of experimental mutagenesis studies. This lets any researcher tap the potential of sophisticated structural analyses enabling a plethora of basic and applied receptor research studies.



中文翻译:

在线 GPCR 结构分析平台

我们提供了一个在线交互式平台,用于比较分析所有可用的 G 蛋白偶联受体 (GPCR) 结构,同时与功能数据相关联。该综合平台包括结构相似性、二级结构、蛋白质骨架包装和运动、残基-残基接触网络、氨基酸特性和实验诱变研究的前瞻性设计。这让任何研究人员都可以挖掘复杂结构分析的潜力,从而进行大量的基础和应用受体研究。

更新日期:2021-11-10
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