Background and Objective

Dexmedetomidine is a highly selective α2-adrenergic receptor agonist with sedative, analgesic, anti-sympathetic and stress-reducing effects. It has been widely used as an adjunct for general anesthesia of multiple surgeries. However, the relationship between the utilization of dexmedetomidine in intestinal surgery and the postoperative inflammatory response of patients remains unclear.

Methods

A randomized, controlled, single-blinded clinical trial was performed. Eighty-six patients assigned for intestinal surgery were recruited and were randomly divided into two groups (dexmedetomidine group, n = 40; control group, n = 40) [six participants were excluded due to multiple reasons, such as allergy and drug use history]. The clinical characteristics and physiological outcomes of participants who received different treatments (dexmedetomidine and 0.9% sodium chloride) were collected and analyzed. Blood samples of the two groups were collected before administration (T0), 10 min after pumping dexmedetomidine/saline solution (T1), immediately after the operation started (T2), 30 min after the operation started (T3), and immediately after the operation ended (T4). Enzyme-linked immunosorbent assay (ELISA) was performed to evaluate the proinflammatory factors.

Results

Intravenous injection of dexmedetomidine before intestinal surgery decreased a variety of circulating proinflammatory factors. Dexmedetomidine alleviated the stress response and promoted the recovery of cognitive ability among patients undergoing intestinal surgery.

Conclusion

Dexmedetomidine administration in patients undergoing intestinal surgery inhibited the surgery-induced inflammatory reactions.

中文翻译：

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右美托咪定对肠道手术患者的抗炎作用：一项随机研究

 背景和目的

右美托咪定是一种高度选择性的α2-肾上腺素受体激动剂，具有镇静、镇痛、抗交感神经和减轻压力的作用。它已被广泛用作多种手术全身麻醉的辅助手段。然而，肠道手术中右美托咪定的使用与患者术后炎症反应的关系尚不清楚。

 方法

进行了一项随机、对照、单盲临床试验。招募了 86 名接受肠道手术的患者，并随机分为两组（右美托咪定组， n = 40；对照组， n = 40）[6 名参与者因过敏和药物使用史等多种原因被排除] 。收集并分析接受不同治疗（右美托咪定和0.9%氯化钠）的参与者的临床特征和生理结果。采集两组血样于给药前(T0)、泵入右美托咪定/盐溶液后10 min(T1)、手术开始后即刻(T2)、手术开始后30 min(T3)、手术后即刻结束（T4）。进行酶联免疫吸附测定（ELISA）来评估促炎因子。

 结果

肠道手术前静脉注射右美托咪定可减少多种循环促炎因子。右美托咪定减轻肠道手术患者的应激反应，促进认知能力的恢复。

 结论

接受肠道手术的患者给予右美托咪定可抑制手术引起的炎症反应。