Asymmetric hydrogenation for the synthesis of 2-substituted chiral morpholines,Chemical Science

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Asymmetric hydrogenation for the synthesis of 2-substituted chiral morpholines
Chemical Science ( IF 7.6 ) Pub Date : 2021-10-28 , DOI: 10.1039/d1sc04288b
Mingxu Li ₁ , Jian Zhang ₁ , Yashi Zou ₁ , Fengfan Zhou ₁ , Zhenfeng Zhang ₁ , Wanbin Zhang _{1,

2}

Affiliation

Asymmetric hydrogenation of unsaturated morpholines has been developed by using a bisphosphine-rhodium catalyst bearing a large bite angle. With this approach, a variety of 2-substituted chiral morpholines could be obtained in quantitative yields and with excellent enantioselectivities (up to 99% ee). The hydrogenated products could be transformed into key intermediates for bioactive compounds.

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